Cerebrospinal fluid inflammatory markers in Parkinson's disease - Associations with depression, fatigue, and cognitive impairment.
Lindqvist, Daniel LU ; Hall, Sara LU ; Surova, Yulia LU ; Nielsen, Henrietta LU ; Janelidze, Shorena LU ; Brundin, Lena LU and Hansson, Oskar LU
(2013)
In Brain Behavior and Immunity
33(Jul.,31).
p.183-189
- Abstract
- Neuroinflammation may be involved in the pathophysiology of Parkinson's disease (PD) and specifically in non-motor symptoms such as depression, fatigue and cognitive impairment. The aim of this study was to measure inflammatory markers in cerebrospinal fluid (CSF) samples from PD patients and a reference group, and to investigate correlations between non-motor symptoms and inflammation. We quantified C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, eotaxin, interferon gamma-induced protein-10, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein 1-β in CSF samples from PD patients (N=87) and the reference group (N=33). Sixteen of the PD patients had a dementia diagnosis (PDD). We assessed... (More)
- Neuroinflammation may be involved in the pathophysiology of Parkinson's disease (PD) and specifically in non-motor symptoms such as depression, fatigue and cognitive impairment. The aim of this study was to measure inflammatory markers in cerebrospinal fluid (CSF) samples from PD patients and a reference group, and to investigate correlations between non-motor symptoms and inflammation. We quantified C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, eotaxin, interferon gamma-induced protein-10, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein 1-β in CSF samples from PD patients (N=87) and the reference group (N=33). Sixteen of the PD patients had a dementia diagnosis (PDD). We assessed symptoms of fatigue, depression, anxiety and cognitive function using the Functional Assessment of Chronic Illness Therapy-Fatigue, the Hospital Anxiety and Depression Scale, and the Mini Mental State Examination, respectively. There were no significant differences in mean levels of inflammatory markers between PD patients and the reference group. After controlling for age, gender and somatic illness, patients with PDD had significantly higher levels of CRP compared to non-demented PD patients (p=0.032) and the reference group (p=0.026). Increased levels of inflammatory markers in CSF were significantly associated with more severe symptoms of depression, anxiety, fatigue, and cognition in the entire PD group. After controlling for PD duration, age, gender, somatic illness and dementia diagnosis, high CRP levels were significantly associated with more severe symptoms of depression (p=0.010) and fatigue (p=0.008), and high MCP-1 levels were significantly associated with more severe symptoms of depression (p=0.032). Our results indicate that non-motor features of PD such as depression, fatigue, and cognitive impairment are associated with higher CSF levels of inflammatory markers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4006217
- author
- Lindqvist, Daniel
LU
; Hall, Sara
LU
; Surova, Yulia
LU
; Nielsen, Henrietta
LU
; Janelidze, Shorena
LU
; Brundin, Lena
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Brain Behavior and Immunity
- volume
- 33
- issue
- Jul.,31
- pages
- 183 - 189
- publisher
- Elsevier
- external identifiers
-
- wos:000324788300022
- pmid:23911592
- scopus:84883771075
- pmid:23911592
- ISSN
- 1090-2139
- DOI
- 10.1016/j.bbi.2013.07.007
- language
- English
- LU publication?
- yes
- id
- 8cc7cfee-2062-484c-a630-abcd8e5f8947 (old id 4006217)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23911592?dopt=Abstract
- date added to LUP
- 2016-04-01 10:34:51
- date last changed
- 2022-04-12 07:35:21
@article{8cc7cfee-2062-484c-a630-abcd8e5f8947,
abstract = {{Neuroinflammation may be involved in the pathophysiology of Parkinson's disease (PD) and specifically in non-motor symptoms such as depression, fatigue and cognitive impairment. The aim of this study was to measure inflammatory markers in cerebrospinal fluid (CSF) samples from PD patients and a reference group, and to investigate correlations between non-motor symptoms and inflammation. We quantified C-reactive protein (CRP), interleukin-6, tumor necrosis factor-alpha, eotaxin, interferon gamma-induced protein-10, monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein 1-β in CSF samples from PD patients (N=87) and the reference group (N=33). Sixteen of the PD patients had a dementia diagnosis (PDD). We assessed symptoms of fatigue, depression, anxiety and cognitive function using the Functional Assessment of Chronic Illness Therapy-Fatigue, the Hospital Anxiety and Depression Scale, and the Mini Mental State Examination, respectively. There were no significant differences in mean levels of inflammatory markers between PD patients and the reference group. After controlling for age, gender and somatic illness, patients with PDD had significantly higher levels of CRP compared to non-demented PD patients (p=0.032) and the reference group (p=0.026). Increased levels of inflammatory markers in CSF were significantly associated with more severe symptoms of depression, anxiety, fatigue, and cognition in the entire PD group. After controlling for PD duration, age, gender, somatic illness and dementia diagnosis, high CRP levels were significantly associated with more severe symptoms of depression (p=0.010) and fatigue (p=0.008), and high MCP-1 levels were significantly associated with more severe symptoms of depression (p=0.032). Our results indicate that non-motor features of PD such as depression, fatigue, and cognitive impairment are associated with higher CSF levels of inflammatory markers.}},
author = {{Lindqvist, Daniel and Hall, Sara and Surova, Yulia and Nielsen, Henrietta and Janelidze, Shorena and Brundin, Lena and Hansson, Oskar}},
issn = {{1090-2139}},
language = {{eng}},
number = {{Jul.,31}},
pages = {{183--189}},
publisher = {{Elsevier}},
series = {{Brain Behavior and Immunity}},
title = {{Cerebrospinal fluid inflammatory markers in Parkinson's disease - Associations with depression, fatigue, and cognitive impairment.}},
url = {{http://dx.doi.org/10.1016/j.bbi.2013.07.007}},
doi = {{10.1016/j.bbi.2013.07.007}},
volume = {{33}},
year = {{2013}},
}