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Distinct growth phases in early life associated with the risk of type 1 diabetes : The teddy study

Liu, Xiang ; Vehik, Kendra LU ; Huang, Yangxin ; Larsson, Helena Elding LU ; Toppari, Jorma ; Ziegler, Anette G. ; She, Jin Xiong ; Rewers, Marian ; Hagopian, William A. and Akolkar, Beena , et al. (2020) In Diabetes Care 43(3). p.556-562
Abstract

OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for a median of 9.0 years (interquartile range 5.7–10.6) with available growth data. Of these, 761 (10.1%) children developed IA and 290 (3.9%) children were diagnosed with T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to estimate children’s individual growth trajectories. Cox proportional hazards models were used to assess the effects... (More)

OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for a median of 9.0 years (interquartile range 5.7–10.6) with available growth data. Of these, 761 (10.1%) children developed IA and 290 (3.9%) children were diagnosed with T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to estimate children’s individual growth trajectories. Cox proportional hazards models were used to assess the effects of associated growth parameters on the risks of IA and progression to T1D. RESULTS A higher rate of weight gain in infancy was associated with increased IA risk (hazard ratio [HR] 1.09 [95% CI 1.02, 1.17] per 1 kg/year). A height growth pattern with a lower rate in infancy (HR 0.79 [95% CI 0.70, 0.90] per 1 cm/year), higher rate in early childhood (HR 1.48 [95% CI 1.22, 1.79] per 1 cm/year), and younger age at the phase transition (HR 0.76 [95% CI 0.58, 0.99] per 1 month) was associated with increased risk of progression from IA to T1D. A higher rate of weight gain in early childhood was associated with increased risk of progression from IA to T1D (HR 2.57 [95% CI 1.34, 4.91] per 1 kg/year) in children with first-appearing GAD autoantibody only. CONCLUSIONS Growth patterns in early life better clarify how specific growth phases are associated with the development of T1D.

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type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
43
issue
3
pages
7 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85081144972
  • pmid:31896601
ISSN
0149-5992
DOI
10.2337/dc19-1670
language
English
LU publication?
yes
id
8cd923cd-008d-46e6-ad50-b0afb476f599
date added to LUP
2021-01-13 09:50:20
date last changed
2024-06-28 08:49:48
@article{8cd923cd-008d-46e6-ad50-b0afb476f599,
  abstract     = {{<p>OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for a median of 9.0 years (interquartile range 5.7–10.6) with available growth data. Of these, 761 (10.1%) children developed IA and 290 (3.9%) children were diagnosed with T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to estimate children’s individual growth trajectories. Cox proportional hazards models were used to assess the effects of associated growth parameters on the risks of IA and progression to T1D. RESULTS A higher rate of weight gain in infancy was associated with increased IA risk (hazard ratio [HR] 1.09 [95% CI 1.02, 1.17] per 1 kg/year). A height growth pattern with a lower rate in infancy (HR 0.79 [95% CI 0.70, 0.90] per 1 cm/year), higher rate in early childhood (HR 1.48 [95% CI 1.22, 1.79] per 1 cm/year), and younger age at the phase transition (HR 0.76 [95% CI 0.58, 0.99] per 1 month) was associated with increased risk of progression from IA to T1D. A higher rate of weight gain in early childhood was associated with increased risk of progression from IA to T1D (HR 2.57 [95% CI 1.34, 4.91] per 1 kg/year) in children with first-appearing GAD autoantibody only. CONCLUSIONS Growth patterns in early life better clarify how specific growth phases are associated with the development of T1D.</p>}},
  author       = {{Liu, Xiang and Vehik, Kendra and Huang, Yangxin and Larsson, Helena Elding and Toppari, Jorma and Ziegler, Anette G. and She, Jin Xiong and Rewers, Marian and Hagopian, William A. and Akolkar, Beena and Krischer, Jeffrey P.}},
  issn         = {{0149-5992}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{556--562}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Distinct growth phases in early life associated with the risk of type 1 diabetes : The teddy study}},
  url          = {{http://dx.doi.org/10.2337/dc19-1670}},
  doi          = {{10.2337/dc19-1670}},
  volume       = {{43}},
  year         = {{2020}},
}