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Transposable elements in the mammalian embryo : pioneers surviving through stealth and service

Gerdes, Patricia LU orcid ; Richardson, Sandra R ; Mager, Dixie L and Faulkner, Geoffrey J (2016) In Genome Biology 17. p.1-17
Abstract

Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Cell Differentiation/genetics, DNA Transposable Elements, Embryonic Development/genetics, Endogenous Retroviruses/genetics, Gene Expression Regulation, Developmental, Humans
in
Genome Biology
volume
17
article number
100
pages
1 - 17
publisher
BioMed Central (BMC)
external identifiers
  • pmid:27161170
  • scopus:84971228919
ISSN
1474-7596
DOI
10.1186/s13059-016-0965-5
language
English
LU publication?
no
id
8d7810d1-0bc1-46dd-9078-c837934874b4
date added to LUP
2024-06-10 16:16:51
date last changed
2024-06-12 03:06:28
@article{8d7810d1-0bc1-46dd-9078-c837934874b4,
  abstract     = {{<p>Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome.</p>}},
  author       = {{Gerdes, Patricia and Richardson, Sandra R and Mager, Dixie L and Faulkner, Geoffrey J}},
  issn         = {{1474-7596}},
  keywords     = {{Animals; Cell Differentiation/genetics; DNA Transposable Elements; Embryonic Development/genetics; Endogenous Retroviruses/genetics; Gene Expression Regulation, Developmental; Humans}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{1--17}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genome Biology}},
  title        = {{Transposable elements in the mammalian embryo : pioneers surviving through stealth and service}},
  url          = {{http://dx.doi.org/10.1186/s13059-016-0965-5}},
  doi          = {{10.1186/s13059-016-0965-5}},
  volume       = {{17}},
  year         = {{2016}},
}