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Involvement of the PI3K/Akt/NF- B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract

Jin, Yuepeng ; Liu, Lewei ; Chen, Bicheng ; Bai, Yongyu ; Zhang, Fan ; Li, Qiang ; Lv, Chongqing ; Sun, Hongwei ; Li, Junjian and Rubby, Sadman , et al. (2017) In BioMed Research International 2017.
Abstract

Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-B) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1β (IL-1β), interleukin-6... (More)

Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-B) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) in the lungs was observed after the induction of SAP. Treatment with SSBE significantly reduced the expression of p-Akt and p-p65 in the lungs and attenuated the severity of SAP-associated ALI compared to the SAP group at 12 h and 24 h. In summary, this study showed that SSBE has beneficial effects on SAP-associated ALI, probably through the PI3-K/Akt signaling pathways by suppressing the NF-B activities.

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publishing date
type
Contribution to journal
publication status
published
subject
in
BioMed Research International
volume
2017
article number
9698410
publisher
Hindawi Limited
external identifiers
  • scopus:85042151672
  • pmid:29359164
ISSN
2314-6133
DOI
10.1155/2017/9698410
language
English
LU publication?
yes
id
8e2586fd-782e-48a0-97a5-dccd6a98aff3
date added to LUP
2018-03-07 14:55:06
date last changed
2025-01-08 06:27:08
@article{8e2586fd-782e-48a0-97a5-dccd6a98aff3,
  abstract     = {{<p>Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-B) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) in the lungs was observed after the induction of SAP. Treatment with SSBE significantly reduced the expression of p-Akt and p-p65 in the lungs and attenuated the severity of SAP-associated ALI compared to the SAP group at 12 h and 24 h. In summary, this study showed that SSBE has beneficial effects on SAP-associated ALI, probably through the PI3-K/Akt signaling pathways by suppressing the NF-B activities.</p>}},
  author       = {{Jin, Yuepeng and Liu, Lewei and Chen, Bicheng and Bai, Yongyu and Zhang, Fan and Li, Qiang and Lv, Chongqing and Sun, Hongwei and Li, Junjian and Rubby, Sadman and Yang, Lihong and Andersson, Roland and Zhou, Mengtao}},
  issn         = {{2314-6133}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{BioMed Research International}},
  title        = {{Involvement of the PI3K/Akt/NF- B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract}},
  url          = {{http://dx.doi.org/10.1155/2017/9698410}},
  doi          = {{10.1155/2017/9698410}},
  volume       = {{2017}},
  year         = {{2017}},
}