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Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients

Naumovska, Magdalena LU ; Sheikh, Rafi LU ; Bengtsson, Boel LU ; Malmsjö, Malin LU and Hammar, Björn LU (2018) In BMC Neurology 18.
Abstract
BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.
METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.
RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p =... (More)
BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.
METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.
RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46).
CONCLUSIONS: The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
BMC Neurology
volume
18
publisher
BioMed Central
external identifiers
  • scopus:85054055669
ISSN
1471-2377
DOI
10.1186/s12883-018-1165-6
language
English
LU publication?
yes
id
8e6264b2-411b-42f1-8bff-2b9656c4815a
date added to LUP
2018-09-30 08:09:33
date last changed
2019-01-06 14:06:37
@article{8e6264b2-411b-42f1-8bff-2b9656c4815a,
  abstract     = {BACKGROUND: To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.<br/>METHODS: Retrospective analysis of patients treated with oral or intravenous high-dose (≥500 mg per day) methylprednisolone for acute ON of unknown or demyelinating etiology. Twenty-eight patients were included in each treatment group. Visual acuity was measured with the Snellen letter chart, color vision with Boström-Kugelberg pseudo-isochromatic plates, and visual field with a Humphrey Field Analyzer.<br/>RESULTS: The treatment results were similar in the two groups at follow-up, with no significant difference in visual acuity (p = 0.54), color vision (p = 0.18), visual field mean deviation (p = 0.39) or the number of highly significantly depressed test points (p = 0.46).<br/>CONCLUSIONS: The results show no clinical disadvantage of using oral high-dose corticosteroids compared to intravenous administration in the treatment of acute ON, which would facilitate the clinical management of these patients.},
  articleno    = {160},
  author       = {Naumovska, Magdalena and Sheikh, Rafi and Bengtsson, Boel and Malmsjö, Malin and Hammar, Björn},
  issn         = {1471-2377},
  language     = {eng},
  month        = {09},
  publisher    = {BioMed Central},
  series       = {BMC Neurology},
  title        = {Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients},
  url          = {http://dx.doi.org/10.1186/s12883-018-1165-6},
  volume       = {18},
  year         = {2018},
}