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Preclinical Evidence for the Role of Stem/Stromal Cells in COPD : Preclinical Evidence for the Role of Stem/Stromal Cells in COPD

Bölükbas, Deniz LU ; Augusto Silva, Iran LU ; Rydell-Törmänen, Kristina LU and Wagner, Darcy LU (2019) p.73-96
Abstract
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and there are currently limited treatment options for these patients. The disease is characterized by a reduction in airflow due to chronic bronchitis, as well as airspace enlargement in the distal lung, resulting in a loss of surface area available for gas exchange. At end-stage disease, oxygen therapy and lung transplantation remain the only potential options. The disease is heterogeneous and both inflammatory cells as well as structural cells are thought to play a role in disease onset and progression. Pharmaceutical approaches are ineffective at reversing disease pathology and currently aim only to provide symptomatic relief. A recent area of... (More)
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and there are currently limited treatment options for these patients. The disease is characterized by a reduction in airflow due to chronic bronchitis, as well as airspace enlargement in the distal lung, resulting in a loss of surface area available for gas exchange. At end-stage disease, oxygen therapy and lung transplantation remain the only potential options. The disease is heterogeneous and both inflammatory cells as well as structural cells are thought to play a role in disease onset and progression. Pharmaceutical approaches are ineffective at reversing disease pathology and currently aim only to provide symptomatic relief. A recent area of investigation focuses on exogenous cell therapy, including stem cell administration, and its potential for directing lung regeneration. Cell therapies from a variety of sources, as well as cell-derived products such as extracellular vesicles, have recently shown efficacy in animal models of COPD, but early clinical trials have not yet shown efficacy. In this chapter, we discuss the different animal models of COPD as well as the studies which have been conducted to date with cell therapies. We conclude the chapter with a discussion regarding the limitations of current animal models and discuss potential areas for future study. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Stem Cell-Based Therapy for Lung Disease
editor
Burgess, Janette K ; Heijink, Irene H. ; and
edition
1
pages
73 - 96
publisher
Springer International Publishing
ISBN
978-3-030-29402-1
978-3-030-29403-8
DOI
10.1007/978-3-030-29403-8_5
language
English
LU publication?
yes
id
8e881791-a4b2-4937-a6c4-951d0776bae0
date added to LUP
2019-12-03 14:28:07
date last changed
2020-01-28 13:52:22
@inbook{8e881791-a4b2-4937-a6c4-951d0776bae0,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and there are currently limited treatment options for these patients. The disease is characterized by a reduction in airflow due to chronic bronchitis, as well as airspace enlargement in the distal lung, resulting in a loss of surface area available for gas exchange. At end-stage disease, oxygen therapy and lung transplantation remain the only potential options. The disease is heterogeneous and both inflammatory cells as well as structural cells are thought to play a role in disease onset and progression. Pharmaceutical approaches are ineffective at reversing disease pathology and currently aim only to provide symptomatic relief. A recent area of investigation focuses on exogenous cell therapy, including stem cell administration, and its potential for directing lung regeneration. Cell therapies from a variety of sources, as well as cell-derived products such as extracellular vesicles, have recently shown efficacy in animal models of COPD, but early clinical trials have not yet shown efficacy. In this chapter, we discuss the different animal models of COPD as well as the studies which have been conducted to date with cell therapies. We conclude the chapter with a discussion regarding the limitations of current animal models and discuss potential areas for future study.},
  author       = {Bölükbas, Deniz and Augusto Silva, Iran and Rydell-Törmänen, Kristina and Wagner, Darcy},
  booktitle    = {Stem Cell-Based Therapy for Lung Disease},
  editor       = {Burgess, Janette K and Heijink, Irene H.},
  isbn         = {978-3-030-29402-1},
  language     = {eng},
  pages        = {73--96},
  publisher    = {Springer International Publishing},
  title        = {Preclinical Evidence for the Role of Stem/Stromal Cells in COPD : Preclinical Evidence for the Role of Stem/Stromal Cells in COPD},
  url          = {http://dx.doi.org/10.1007/978-3-030-29403-8_5},
  doi          = {10.1007/978-3-030-29403-8_5},
  year         = {2019},
}