Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial
(2005) In American Journal of Clinical Nutrition 82(5). p.1115-1126- Abstract
- BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTIVE: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. DESIGN: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray... (More)
- BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTIVE: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. DESIGN: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. RESULTS: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. CONCLUSIONS: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1133554
- author
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Growth, nutrition intervention, pubertal girls, bone property
- in
- American Journal of Clinical Nutrition
- volume
- 82
- issue
- 5
- pages
- 1115 - 1126
- publisher
- Oxford University Press
- external identifiers
-
- pmid:16280447
- scopus:32944478966
- ISSN
- 1938-3207
- language
- English
- LU publication?
- no
- id
- 8eea26ef-be0d-4194-859f-a9ac6bb04bac (old id 1133554)
- alternative location
- http://www.ajcn.org/cgi/content/abstract/82/5/1115
- date added to LUP
- 2016-04-01 16:20:07
- date last changed
- 2022-03-30 07:04:15
@article{8eea26ef-be0d-4194-859f-a9ac6bb04bac,
abstract = {{BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTIVE: The purpose was to examine the effects of both food-based and pill supplements of calcium and vitamin D on bone mass and body composition in girls aged 10-12 y. DESIGN: This placebo-controlled intervention trial randomly assigned 195 healthy girls at Tanner stage I-II, aged 10-12 y, with dietary calcium intakes <900 mg/d to 1 of 4 groups: calcium (1000 mg) + vitamin D3 (200 IU), calcium (1000 mg), cheese (1000 mg calcium), and placebo. Primary outcomes were bone indexes of the hip, spine, and whole body by dual-energy X-ray absorptiometry and of the radius and tibia by peripheral quantitative computed tomography. RESULTS: With the use of intention-to-treat or efficacy analysis, calcium supplementation with cheese resulted in a higher percentage change in cortical thickness of the tibia than did placebo, calcium, or calcium + vitamin D treatment (P = 0.01, 0.038, and 0.004, respectively) and in higher whole-body bone mineral density than did placebo treatment (P = 0.044) when compliance was >50%. With the use of a hierarchical linear model with random effects to control for growth velocity, these differences disappeared. CONCLUSIONS: Increasing calcium intake by consuming cheese appears to be more beneficial for cortical bone mass accrual than the consumption of tablets containing a similar amount of calcium. Diverse patterns of growth velocity may mask the efficacy of supplementation in a short-term trial of children transiting through puberty.}},
author = {{Cheng, Sulin and Lyytikainen, Arja and Kroger, Heikki and Lamberg-Allardt, Christel and Alen, Markku and Koistinen, Arvo and Wang, Qing Ju and Suuriniemi, Miia and Suominen, Harri and Mahonen, Anitta and Nicholson, Patrick H F and Ivaska, Kaisa and Korpela, Riitta and Ohlsson, Clae}},
issn = {{1938-3207}},
keywords = {{Growth; nutrition intervention; pubertal girls; bone property}},
language = {{eng}},
number = {{5}},
pages = {{1115--1126}},
publisher = {{Oxford University Press}},
series = {{American Journal of Clinical Nutrition}},
title = {{Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial}},
url = {{http://www.ajcn.org/cgi/content/abstract/82/5/1115}},
volume = {{82}},
year = {{2005}},
}