Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids

Danieli, B ; Giardini, A ; Lesma, G ; Passarella, D ; Silvani, A ; Appendino, G ; Noncovich, A ; Fontana, G ; Bombardelli, E and Sterner, Olov LU (2004) In Chemistry and Biodiversity 1(2). p.327-345
Abstract
The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemistry and Biodiversity
volume
1
issue
2
pages
327 - 345
publisher
Verlag Helvetica Chimica Acta
external identifiers
  • wos:000223765500010
  • scopus:33645504486
ISSN
1612-1872
DOI
10.1002/cbdv.200490029
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
8efb5aa3-5848-4ab1-b714-1c4703619f25 (old id 141179)
date added to LUP
2016-04-01 11:33:43
date last changed
2022-01-26 07:03:42
@article{8efb5aa3-5848-4ab1-b714-1c4703619f25,
  abstract     = {{The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.}},
  author       = {{Danieli, B and Giardini, A and Lesma, G and Passarella, D and Silvani, A and Appendino, G and Noncovich, A and Fontana, G and Bombardelli, E and Sterner, Olov}},
  issn         = {{1612-1872}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{327--345}},
  publisher    = {{Verlag Helvetica Chimica Acta}},
  series       = {{Chemistry and Biodiversity}},
  title        = {{Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids}},
  url          = {{http://dx.doi.org/10.1002/cbdv.200490029}},
  doi          = {{10.1002/cbdv.200490029}},
  volume       = {{1}},
  year         = {{2004}},
}