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Confirmation of quantitative trait loci for somatic cell score on bovine chromosome 18 in the German Holstein

Xu, Ningying ; Paul, Sven ; Bennewitz, Jörn ; Reinsch, Norbert ; Thaller, Georg ; Reinhardt, Friedrich ; Kühn, Christa ; Schwerin, Manfred ; Erhardt, Georg and Weimann, Christina , et al. (2006) In Archiv fur Tierzucht 49(2). p.111-119
Abstract

Fifty-one half-sib families with 2768 sires were selected for this study to confirm a quantitative trait locus (QTL) detected within a previous project initiated by the German Cattle Breeders Federation (ADR). The data based on a granddaughter design were divided into two parts and were analysed using linear models and paternal half sib regression methods. The results strongly support the hypothesis that the chromosomal region around marker TGLA227 at the telomeric end of chromosome 18 harbours a QTL for somatic cell score (SCS) in the German Holstein population. Using a two-QTL model the analysis showed evidence for another QTL for SCS in that region on chromosome 18. Further fine mapping studies should be carried out to decide on the... (More)

Fifty-one half-sib families with 2768 sires were selected for this study to confirm a quantitative trait locus (QTL) detected within a previous project initiated by the German Cattle Breeders Federation (ADR). The data based on a granddaughter design were divided into two parts and were analysed using linear models and paternal half sib regression methods. The results strongly support the hypothesis that the chromosomal region around marker TGLA227 at the telomeric end of chromosome 18 harbours a QTL for somatic cell score (SCS) in the German Holstein population. Using a two-QTL model the analysis showed evidence for another QTL for SCS in that region on chromosome 18. Further fine mapping studies should be carried out to decide on the two QTL hypothesis.

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publishing date
type
Contribution to journal
publication status
published
keywords
Chromosome 18, German Holsteins, QTL, Somatic cell score, Udder health
in
Archiv fur Tierzucht
volume
49
issue
2
pages
9 pages
publisher
Forschungsinstitut fuer die Biologie Landwirtschaftlicher Nutztiere
external identifiers
  • scopus:85063821873
  • scopus:33646242529
ISSN
0003-9438
DOI
10.5194/aab-49-111-2006
language
English
LU publication?
no
id
8f14af8a-32c8-4b13-95e7-c1dab4a69ed9
date added to LUP
2018-10-10 13:32:57
date last changed
2024-03-16 02:53:19
@article{8f14af8a-32c8-4b13-95e7-c1dab4a69ed9,
  abstract     = {{<p>Fifty-one half-sib families with 2768 sires were selected for this study to confirm a quantitative trait locus (QTL) detected within a previous project initiated by the German Cattle Breeders Federation (ADR). The data based on a granddaughter design were divided into two parts and were analysed using linear models and paternal half sib regression methods. The results strongly support the hypothesis that the chromosomal region around marker TGLA227 at the telomeric end of chromosome 18 harbours a QTL for somatic cell score (SCS) in the German Holstein population. Using a two-QTL model the analysis showed evidence for another QTL for SCS in that region on chromosome 18. Further fine mapping studies should be carried out to decide on the two QTL hypothesis.</p>}},
  author       = {{Xu, Ningying and Paul, Sven and Bennewitz, Jörn and Reinsch, Norbert and Thaller, Georg and Reinhardt, Friedrich and Kühn, Christa and Schwerin, Manfred and Erhardt, Georg and Weimann, Christina and Thomsen, Hauke and Mishra, Sharad and Kalm, Ernst}},
  issn         = {{0003-9438}},
  keywords     = {{Chromosome 18; German Holsteins; QTL; Somatic cell score; Udder health}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{2}},
  pages        = {{111--119}},
  publisher    = {{Forschungsinstitut fuer die Biologie Landwirtschaftlicher Nutztiere}},
  series       = {{Archiv fur Tierzucht}},
  title        = {{Confirmation of quantitative trait loci for somatic cell score on bovine chromosome 18 in the German Holstein}},
  url          = {{http://dx.doi.org/10.5194/aab-49-111-2006}},
  doi          = {{10.5194/aab-49-111-2006}},
  volume       = {{49}},
  year         = {{2006}},
}