Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Phthalate levels in indoor dust and associations to croup in the SELMA study

Preece, Anna Sofia ; Shu, Huan ; Knutz, Malin ; Krais, Annette M. LU orcid ; Wikström, Sverre and Bornehag, Carl Gustaf LU (2021) In Journal of Exposure Science and Environmental Epidemiology 31(2). p.257-265
Abstract

Phthalates are ubiquitous indoor pollutants which have been associated with child airway disease although results are inconclusive. This study examined associations between phthalate levels in residential indoor dust and croup during infancy. Settled indoor dust was collected in 482 homes of 6-month-old infants in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study and analysed for seven phthalates and one phthalate replacement using gas chromatography tandem mass spectrometry. The incidence of parental reported croup at 12 months was 6.4% for girls and 13.4% for boys. Associations between phthalate dust levels and croup were analysed by logistic regression adjusted for potential confounders. We... (More)

Phthalates are ubiquitous indoor pollutants which have been associated with child airway disease although results are inconclusive. This study examined associations between phthalate levels in residential indoor dust and croup during infancy. Settled indoor dust was collected in 482 homes of 6-month-old infants in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study and analysed for seven phthalates and one phthalate replacement using gas chromatography tandem mass spectrometry. The incidence of parental reported croup at 12 months was 6.4% for girls and 13.4% for boys. Associations between phthalate dust levels and croup were analysed by logistic regression adjusted for potential confounders. We found significant associations between di-ethyl phthalate (DEP) and di-ethyl-hexyl phthalate (DEHP) in residential dust and parental reported croup (adjusted odds ratio (aOR) = 1.71; 95% CI: 1.08–2.73 and 2.07; 1.00–4.30, respectively). Stratified results for boys showed significant associations between DEP and butyl-benzyl phthalate (BBzP) in dust and infant croup (aOR = 1.86; 95% CI: 1.04–3.34 and 2.02; 1.04–3.90, respectively). Results for girls had questionable statistical power due to few cases. Our results suggest that exposure to phthalates in dust is a risk factor for airway inflammatory responses in infant children.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Croup, Dust, Exposure, Phthalate, SELMA study
in
Journal of Exposure Science and Environmental Epidemiology
volume
31
issue
2
pages
257 - 265
publisher
Nature Publishing Group
external identifiers
  • scopus:85091157156
  • pmid:32952153
ISSN
1559-0631
DOI
10.1038/s41370-020-00264-7
language
English
LU publication?
yes
id
8f2fb9d3-87d4-48e1-bdba-4787c71ae89a
date added to LUP
2020-11-20 14:50:53
date last changed
2024-05-01 20:15:46
@article{8f2fb9d3-87d4-48e1-bdba-4787c71ae89a,
  abstract     = {{<p>Phthalates are ubiquitous indoor pollutants which have been associated with child airway disease although results are inconclusive. This study examined associations between phthalate levels in residential indoor dust and croup during infancy. Settled indoor dust was collected in 482 homes of 6-month-old infants in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study and analysed for seven phthalates and one phthalate replacement using gas chromatography tandem mass spectrometry. The incidence of parental reported croup at 12 months was 6.4% for girls and 13.4% for boys. Associations between phthalate dust levels and croup were analysed by logistic regression adjusted for potential confounders. We found significant associations between di-ethyl phthalate (DEP) and di-ethyl-hexyl phthalate (DEHP) in residential dust and parental reported croup (adjusted odds ratio (aOR) = 1.71; 95% CI: 1.08–2.73 and 2.07; 1.00–4.30, respectively). Stratified results for boys showed significant associations between DEP and butyl-benzyl phthalate (BBzP) in dust and infant croup (aOR = 1.86; 95% CI: 1.04–3.34 and 2.02; 1.04–3.90, respectively). Results for girls had questionable statistical power due to few cases. Our results suggest that exposure to phthalates in dust is a risk factor for airway inflammatory responses in infant children.</p>}},
  author       = {{Preece, Anna Sofia and Shu, Huan and Knutz, Malin and Krais, Annette M. and Wikström, Sverre and Bornehag, Carl Gustaf}},
  issn         = {{1559-0631}},
  keywords     = {{Croup; Dust; Exposure; Phthalate; SELMA study}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{257--265}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Exposure Science and Environmental Epidemiology}},
  title        = {{Phthalate levels in indoor dust and associations to croup in the SELMA study}},
  url          = {{http://dx.doi.org/10.1038/s41370-020-00264-7}},
  doi          = {{10.1038/s41370-020-00264-7}},
  volume       = {{31}},
  year         = {{2021}},
}