New drugs from the sea
(2004) In Journal of Chemotherapy 16(Suppl 4). p.9-86- Abstract
This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some... (More)
This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some of them appear to act by mechanisms different from those of conventional chemotherapeutic drugs and thus may be effective against tumors for which no active drugs are available.
(Less)
- author
- D'Incalci, Maurizio ; de Simone, M ; Tavecchio, M LU ; Damia, Giovanna ; Garbi, A and Erba, Eugenio
- publishing date
- 2004-11
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Antineoplastic Agents, Alkylating, Apoptosis, Depsipeptides, Dioxoles, Humans, Isoquinolines, Marine Biology, Pharmaceutical Preparations, Sensitivity and Specificity, Structure-Activity Relationship, Tetrahydroisoquinolines, Tumor Cells, Cultured
- in
- Journal of Chemotherapy
- volume
- 16
- issue
- Suppl 4
- pages
- 4 pages
- publisher
- Italian Society of Chemotherapy
- external identifiers
-
- pmid:15688619
- scopus:11244266038
- ISSN
- 1120-009X
- DOI
- 10.1179/joc.2004.16.Supplement-1.86
- language
- English
- LU publication?
- no
- id
- 8f32e34c-92b4-4c91-be78-98bc40ccf8b8
- date added to LUP
- 2017-03-07 09:16:01
- date last changed
- 2024-01-13 16:23:50
@article{8f32e34c-92b4-4c91-be78-98bc40ccf8b8,
abstract = {{<p>This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some of them appear to act by mechanisms different from those of conventional chemotherapeutic drugs and thus may be effective against tumors for which no active drugs are available.</p>}},
author = {{D'Incalci, Maurizio and de Simone, M and Tavecchio, M and Damia, Giovanna and Garbi, A and Erba, Eugenio}},
issn = {{1120-009X}},
keywords = {{Animals; Antineoplastic Agents, Alkylating; Apoptosis; Depsipeptides; Dioxoles; Humans; Isoquinolines; Marine Biology; Pharmaceutical Preparations; Sensitivity and Specificity; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured}},
language = {{eng}},
number = {{Suppl 4}},
pages = {{9--86}},
publisher = {{Italian Society of Chemotherapy}},
series = {{Journal of Chemotherapy}},
title = {{New drugs from the sea}},
url = {{http://dx.doi.org/10.1179/joc.2004.16.Supplement-1.86}},
doi = {{10.1179/joc.2004.16.Supplement-1.86}},
volume = {{16}},
year = {{2004}},
}