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New drugs from the sea

D'Incalci, Maurizio; de Simone, M; Tavecchio, M LU ; Damia, Giovanna; Garbi, A and Erba, Eugenio (2004) In Journal of Chemotherapy 16(Suppl 4). p.9-86
Abstract

This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some... (More)

This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some of them appear to act by mechanisms different from those of conventional chemotherapeutic drugs and thus may be effective against tumors for which no active drugs are available.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Antineoplastic Agents, Alkylating, Apoptosis, Depsipeptides, Dioxoles, Humans, Isoquinolines, Marine Biology, Pharmaceutical Preparations, Sensitivity and Specificity, Structure-Activity Relationship, Tetrahydroisoquinolines, Tumor Cells, Cultured
in
Journal of Chemotherapy
volume
16
issue
Suppl 4
pages
4 pages
publisher
Italian Society of Chemotherapy
external identifiers
  • scopus:11244266038
ISSN
1120-009X
DOI
10.1179/joc.2004.16.Supplement-1.86
language
English
LU publication?
no
id
8f32e34c-92b4-4c91-be78-98bc40ccf8b8
date added to LUP
2017-03-07 09:16:01
date last changed
2017-05-30 10:32:09
@article{8f32e34c-92b4-4c91-be78-98bc40ccf8b8,
  abstract     = {<p>This paper illustrates some biochemical and pharmacological properties of two natural marine products such as trabectedin (ET-743, Yondelis) and aplidine. Trabectedin has shown clinical antitumor activity in refractory soft tissue sarcoma and ovarian cancer. The lack of cross resistance of trabectedin with other chemotherapeutic drugs is presumably related to its peculiar mode of action, that seems to be related to a promoter-dependent transcription modulation. Aplidine is a potent pro-apoptotic inducer in human leukemia and has antiangiogenic properties. These examples support the view that more research should be carried out to investigate new natural marine products since there are compounds among them with antitumor properties. Some of them appear to act by mechanisms different from those of conventional chemotherapeutic drugs and thus may be effective against tumors for which no active drugs are available.</p>},
  author       = {D'Incalci, Maurizio and de Simone, M and Tavecchio, M and Damia, Giovanna and Garbi, A and Erba, Eugenio},
  issn         = {1120-009X},
  keyword      = {Animals,Antineoplastic Agents, Alkylating,Apoptosis,Depsipeptides,Dioxoles,Humans,Isoquinolines,Marine Biology,Pharmaceutical Preparations,Sensitivity and Specificity,Structure-Activity Relationship,Tetrahydroisoquinolines,Tumor Cells, Cultured},
  language     = {eng},
  number       = {Suppl 4},
  pages        = {9--86},
  publisher    = {Italian Society of Chemotherapy},
  series       = {Journal of Chemotherapy},
  title        = {New drugs from the sea},
  url          = {http://dx.doi.org/10.1179/joc.2004.16.Supplement-1.86},
  volume       = {16},
  year         = {2004},
}