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Serum calcium, even within normal range, is associated with blood pressure with a potential influence of calcium intake

Dal Pont, Chiara ; Sartorio, Andrea ; Giontella, Alice LU orcid ; Rosin, Elena ; Cangiano, Caterina ; Zanconato, Valentina ; Marin, Sara ; Bertucci, Fabio ; Grisenti, Silvia and Stocchetti, Federica , et al. (2026) In Journal of the Endocrine Society 10(5).
Abstract

Context: Even within the physiological range, serum calcium (sCa++) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa2+ and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa2+ was measured in patients referred for suspected secondary hypertension (VerHyperReg; n = 81) and in 2 population-based cohorts: the Malmö Preventive Project (MPP; n = 18 240) and the UK Biobank (UKB; n≈330 000). Calcium intake was assessed in the Malmö Diet and Cancer Study (MDC; n = 28 098) and in a subsample of MPP participants (MPP×MDC; n =... (More)

Context: Even within the physiological range, serum calcium (sCa++) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa2+ and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa2+ was measured in patients referred for suspected secondary hypertension (VerHyperReg; n = 81) and in 2 population-based cohorts: the Malmö Preventive Project (MPP; n = 18 240) and the UK Biobank (UKB; n≈330 000). Calcium intake was assessed in the Malmö Diet and Cancer Study (MDC; n = 28 098) and in a subsample of MPP participants (MPP×MDC; n = 4095). Multivariable regression models were used to analyze the associations. Results: In MPP and UKB, sCa2+ was positively associated with systolic and diastolic BP (even within the normal range). In VerHyperReg, sCa2+ was associated with central systolic BP. In the MDC, higher calcium intake was inversely associated with BP. In MPP×MDC, sCa2+ was positively associated with systolic BP in the lower 3 quartiles of intake, whereas this association was reversed in the highest quartile. Conclusion: Serum calcium levels within the normal range are positively associated with BP. Increased dietary calcium intake may attenuate this relationship, thus suggesting a modulatory role in BP regulation. Further investigations are warranted.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood pressure, calcium intake, calcium metabolism, hypertension
in
Journal of the Endocrine Society
volume
10
issue
5
publisher
Oxford University Press
external identifiers
  • scopus:105037833209
  • pmid:42088095
ISSN
2472-1972
DOI
10.1210/jendso/bvag031
language
English
LU publication?
yes
id
8f33b187-3cde-42d8-b425-7e404b50a63e
date added to LUP
2026-07-09 15:25:49
date last changed
2026-09-03 20:28:04
@article{8f33b187-3cde-42d8-b425-7e404b50a63e,
  abstract     = {{<p>Context: Even within the physiological range, serum calcium (sCa<sup>++</sup>) may influence vascular tone and blood pressure (BP); however, the potential modulatory role of dietary calcium intake remains unclear. Objective: To investigate the association between sCa<sup>2+</sup> and BP (including central BP) and to assess whether calcium intake affects this relationship. Methods: sCa<sup>2+</sup> was measured in patients referred for suspected secondary hypertension (VerHyperReg; n = 81) and in 2 population-based cohorts: the Malmö Preventive Project (MPP; n = 18 240) and the UK Biobank (UKB; n≈330 000). Calcium intake was assessed in the Malmö Diet and Cancer Study (MDC; n = 28 098) and in a subsample of MPP participants (MPP×MDC; n = 4095). Multivariable regression models were used to analyze the associations. Results: In MPP and UKB, sCa<sup>2+</sup> was positively associated with systolic and diastolic BP (even within the normal range). In VerHyperReg, sCa<sup>2+</sup> was associated with central systolic BP. In the MDC, higher calcium intake was inversely associated with BP. In MPP×MDC, sCa<sup>2+</sup> was positively associated with systolic BP in the lower 3 quartiles of intake, whereas this association was reversed in the highest quartile. Conclusion: Serum calcium levels within the normal range are positively associated with BP. Increased dietary calcium intake may attenuate this relationship, thus suggesting a modulatory role in BP regulation. Further investigations are warranted.</p>}},
  author       = {{Dal Pont, Chiara and Sartorio, Andrea and Giontella, Alice and Rosin, Elena and Cangiano, Caterina and Zanconato, Valentina and Marin, Sara and Bertucci, Fabio and Grisenti, Silvia and Stocchetti, Federica and Cattazzo, Filippo and Bonafini, Sara and Ericson, Ulrika and Orho-Melander, Marju and Melander, Olle and Fava, Cristiano}},
  issn         = {{2472-1972}},
  keywords     = {{blood pressure; calcium intake; calcium metabolism; hypertension}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of the Endocrine Society}},
  title        = {{Serum calcium, even within normal range, is associated with blood pressure with a potential influence of calcium intake}},
  url          = {{http://dx.doi.org/10.1210/jendso/bvag031}},
  doi          = {{10.1210/jendso/bvag031}},
  volume       = {{10}},
  year         = {{2026}},
}