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Data Descriptor : Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations

Lagali, Neil S.; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza A.; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus and Dahlin, Lars B. LU , et al. (2018) In Scientific Data 5.
Abstract

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of... (More)

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of the same age. To maximize reuse, the dataset includes bilateral eye data, associated clinical parameters, and machine-generated SBP nerve density values obtained through automatic segmentation and nerve tracing algorithms. The dataset can be used to examine nerve degradation patterns to develop tools to non-invasively monitor diabetes progression while avoiding narrow-field imaging and image selection biases.

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published
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Scientific Data
volume
5
publisher
Nature Publishing Group
external identifiers
  • scopus:85045880797
ISSN
2052-4463
DOI
10.1038/sdata.2018.75
language
English
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yes
id
8f42c1fb-cd1b-4385-98ac-00c489f7d442
date added to LUP
2018-05-04 08:34:03
date last changed
2019-01-14 07:39:51
@article{8f42c1fb-cd1b-4385-98ac-00c489f7d442,
  abstract     = {<p>A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of the same age. To maximize reuse, the dataset includes bilateral eye data, associated clinical parameters, and machine-generated SBP nerve density values obtained through automatic segmentation and nerve tracing algorithms. The dataset can be used to examine nerve degradation patterns to develop tools to non-invasively monitor diabetes progression while avoiding narrow-field imaging and image selection biases.</p>},
  articleno    = {180075},
  author       = {Lagali, Neil S. and Allgeier, Stephan and Guimarães, Pedro and Badian, Reza A. and Ruggeri, Alfredo and Köhler, Bernd and Utheim, Tor Paaske and Peebo, Beatrice and Peterson, Magnus and Dahlin, Lars B. and Rolandsson, Olov},
  issn         = {2052-4463},
  language     = {eng},
  month        = {04},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Data},
  title        = {Data Descriptor : Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations},
  url          = {http://dx.doi.org/10.1038/sdata.2018.75},
  volume       = {5},
  year         = {2018},
}