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Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies

Fasanya, Adebimpe ; Mohammed, Nurat ; Saleh, Bandar Hasan LU ; Tijani, Muyideen Kolapo LU ; Teleka, Alexandra LU ; Quintana, Maria Del Pilar ; Hviid, Lars and Persson, Kristina E M LU (2023) In Frontiers in cellular and infection microbiology 13.
Abstract

Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is... (More)

Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Pregnancy, Female, Pregnant Women, Malaria, Falciparum, Nigeria/epidemiology, Phosphatidylserines, Malaria/complications, Anemia/complications, Immunoglobulin G, Plasmodium falciparum, Antigens, Protozoan, Antibodies, Protozoan
in
Frontiers in cellular and infection microbiology
volume
13
article number
1130186
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85153487512
  • pmid:37091678
ISSN
2235-2988
DOI
10.3389/fcimb.2023.1130186
language
English
LU publication?
yes
additional info
Copyright © 2023 Fasanya, Mohammed, Saleh, Tijani, Teleka, Quintana, Hviid and Persson.
id
8f4d8b20-0f8f-4555-999d-1b5cf327e622
date added to LUP
2023-05-23 13:06:51
date last changed
2024-06-15 03:16:01
@article{8f4d8b20-0f8f-4555-999d-1b5cf327e622,
  abstract     = {{<p>Anemia is a common malaria-associated complication in pregnant women in endemic regions. Phosphatidylserine (PS) is exposed to the immune system during the massive destruction of red blood cells (RBCs) that accompany malaria, and antibodies against PS have been linked to anemia through destruction of uninfected RBCs. We determined levels of anti-PS IgG antibodies in pregnant women in Ibadan, Nigeria and correlated them to parameters of importance in development of anemia and immunity. Anti-PS correlated inversely with Packed Cell Volume (PCV), indicating that the antibodies could contribute to anemia. There was no correlation with anti-VAR2CSA IgG, haptoglobin or parasitemia, indicating that the modulation of anti-PS response is multifactorial in nature. Anti-PS levels were lowest in multigravidae compared to both primigravidae and secundigravidae and correlated inversely with age. In conclusion, lower levels of anti-PS in multigravidae could be beneficial in avoiding anemia.</p>}},
  author       = {{Fasanya, Adebimpe and Mohammed, Nurat and Saleh, Bandar Hasan and Tijani, Muyideen Kolapo and Teleka, Alexandra and Quintana, Maria Del Pilar and Hviid, Lars and Persson, Kristina E M}},
  issn         = {{2235-2988}},
  keywords     = {{Humans; Pregnancy; Female; Pregnant Women; Malaria, Falciparum; Nigeria/epidemiology; Phosphatidylserines; Malaria/complications; Anemia/complications; Immunoglobulin G; Plasmodium falciparum; Antigens, Protozoan; Antibodies, Protozoan}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in cellular and infection microbiology}},
  title        = {{Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies}},
  url          = {{http://dx.doi.org/10.3389/fcimb.2023.1130186}},
  doi          = {{10.3389/fcimb.2023.1130186}},
  volume       = {{13}},
  year         = {{2023}},
}