Myocardial injury biomarkers at point of care for early identification of primary graft dysfunction after heart transplantation
Jernryd, Victoria LU ; Metzsch, Carsten LU ; Andersson, Bodil LU
; Smith, J Gustav
LU
and Nilsson, Johan
LU
(2022)
In Clinical Transplantation
36(2).
- Abstract
INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.
METHODS: Blood samples from the coronary sinus were obtained at the time of transplantation in hearts preserved by cold static storage. The samples were analyzed for CK-MB and cTnI with a point-of-care method. The primary outcome was severe PGD or the need for veno-arterial extracorporeal membrane oxygenation within 7 days, referred to as severe graft dysfunction.
RESULTS: Of the total cohort (n... (More)
INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.
METHODS: Blood samples from the coronary sinus were obtained at the time of transplantation in hearts preserved by cold static storage. The samples were analyzed for CK-MB and cTnI with a point-of-care method. The primary outcome was severe PGD or the need for veno-arterial extracorporeal membrane oxygenation within 7 days, referred to as severe graft dysfunction.
RESULTS: Of the total cohort (n = 63), eight patients (13%) were diagnosed with severe graft dysfunction within 7 days. Patients with high CK-MB had an increased risk for severe graft dysfunction with unadjusted Odds Ratio (OR) of 4.5 (95%CI .96-21.11 P = .057) and adjusted OR of 7.4 (95%CI 1.13-48.46, P = .037. Similar but non significant trends were observed for cTnI.
CONCLUSION: By measuring CK-MB from the coronary effluent in the donor heart, it may be possible to identify patients at increased risk for severe PGD after heart transplantation.
(Less)
- author
- Jernryd, Victoria
LU
; Metzsch, Carsten
LU
; Andersson, Bodil
LU
; Smith, J Gustav
LU
and Nilsson, Johan
LU
- organization
-
- Artificial Intelligence in CardioThoracic Sciences (AICTS) (research group)
- Thoracic Surgery
- Cardiothoracic anesthesia and intensive care (research group)
- Less invasive cardiac surgery (research group)
- Anesthesiology and Intensive Care
- Hepato-Pancreato-Biliary Surgery (research group)
- Surgery (Lund)
- WCMM-Wallenberg Centre for Molecular Medicine
- Heart Failure and Mechanical Support (research group)
- Cardiovascular Epigenetics (research group)
- Cardiology
- EpiHealth: Epidemiology for Health
- EXODIAB: Excellence of Diabetes Research in Sweden
- Molecular Epidemiology and Cardiology (research group)
- Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS) (research group)
- Heart and Lung transplantation (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Transplantation
- volume
- 36
- issue
- 2
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85120577665
- pmid:34738670
- ISSN
- 1399-0012
- DOI
- 10.1111/ctr.14526
- language
- English
- LU publication?
- yes
- additional info
- © 2021 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd.
- id
- 8f4df24a-c2ad-420c-9369-1b2a8bae7b50
- date added to LUP
- 2022-01-17 15:21:46
- date last changed
- 2024-05-04 20:09:39
@article{8f4df24a-c2ad-420c-9369-1b2a8bae7b50,
abstract = {{<p>INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.</p><p>METHODS: Blood samples from the coronary sinus were obtained at the time of transplantation in hearts preserved by cold static storage. The samples were analyzed for CK-MB and cTnI with a point-of-care method. The primary outcome was severe PGD or the need for veno-arterial extracorporeal membrane oxygenation within 7 days, referred to as severe graft dysfunction.</p><p>RESULTS: Of the total cohort (n = 63), eight patients (13%) were diagnosed with severe graft dysfunction within 7 days. Patients with high CK-MB had an increased risk for severe graft dysfunction with unadjusted Odds Ratio (OR) of 4.5 (95%CI .96-21.11 P = .057) and adjusted OR of 7.4 (95%CI 1.13-48.46, P = .037. Similar but non significant trends were observed for cTnI.</p><p>CONCLUSION: By measuring CK-MB from the coronary effluent in the donor heart, it may be possible to identify patients at increased risk for severe PGD after heart transplantation.</p>}},
author = {{Jernryd, Victoria and Metzsch, Carsten and Andersson, Bodil and Smith, J Gustav and Nilsson, Johan}},
issn = {{1399-0012}},
language = {{eng}},
number = {{2}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Transplantation}},
title = {{Myocardial injury biomarkers at point of care for early identification of primary graft dysfunction after heart transplantation}},
url = {{http://dx.doi.org/10.1111/ctr.14526}},
doi = {{10.1111/ctr.14526}},
volume = {{36}},
year = {{2022}},
}