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In vitro assays for investigating the FLASH effect

Adrian, Gabriel LU orcid ; Ruan, Jia Ling ; Paillas, Salomé ; Cooper, Christian R. and Petersson, Kristoffer LU (2022) In Expert Reviews in Molecular Medicine 24.
Abstract

FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding of the specific beam parameters that induces a FLASH effect, environmental conditions affecting the response, and the radiobiological mechanisms involved. Even though the FLASH effect has generally been considered as an in vivo effect, studies finding these answers would be difficult and ethically challenging to carry out solely in animals.... (More)

FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding of the specific beam parameters that induces a FLASH effect, environmental conditions affecting the response, and the radiobiological mechanisms involved. Even though the FLASH effect has generally been considered as an in vivo effect, studies finding these answers would be difficult and ethically challenging to carry out solely in animals. Hence, suitable in vitro studies aimed towards finding these answers are needed. In this review, we describe and summarise several in vitro assays that have been used or could be used to finally elucidate the mechanisms behind the FLASH effect.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell models, cells, dose rate, radiation, radiotherapy, ultra-high
in
Expert Reviews in Molecular Medicine
volume
24
article number
e10
publisher
Cambridge University Press
external identifiers
  • scopus:85125426994
  • pmid:35225211
ISSN
1462-3994
DOI
10.1017/erm.2022.5
language
English
LU publication?
yes
id
8f5ee1a1-a3e1-4893-b318-17a927f73906
date added to LUP
2022-04-14 11:08:36
date last changed
2024-06-20 01:48:27
@article{8f5ee1a1-a3e1-4893-b318-17a927f73906,
  abstract     = {{<p>FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding of the specific beam parameters that induces a FLASH effect, environmental conditions affecting the response, and the radiobiological mechanisms involved. Even though the FLASH effect has generally been considered as an in vivo effect, studies finding these answers would be difficult and ethically challenging to carry out solely in animals. Hence, suitable in vitro studies aimed towards finding these answers are needed. In this review, we describe and summarise several in vitro assays that have been used or could be used to finally elucidate the mechanisms behind the FLASH effect.</p>}},
  author       = {{Adrian, Gabriel and Ruan, Jia Ling and Paillas, Salomé and Cooper, Christian R. and Petersson, Kristoffer}},
  issn         = {{1462-3994}},
  keywords     = {{Cell models; cells; dose rate; radiation; radiotherapy; ultra-high}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Cambridge University Press}},
  series       = {{Expert Reviews in Molecular Medicine}},
  title        = {{In vitro assays for investigating the FLASH effect}},
  url          = {{http://dx.doi.org/10.1017/erm.2022.5}},
  doi          = {{10.1017/erm.2022.5}},
  volume       = {{24}},
  year         = {{2022}},
}