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Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices

Persson, Henrik LU ; Park, Siwan ; Mohan, Michael ; Young, Edmond and Simmons, Craig A. (2019) 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 p.1666-1667
Abstract

We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solvent distribution, and force application to create strong, leak-free bonds. The devices are evaluated for suitability for modelling biological barriers by culturing endothelial cells and measuring permeability using a plate reader.

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author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Laser cutting, Milling, Organ-on-a-chip, PET, PMMA, Solvent bonding, Thermoplastics
host publication
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
series title
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
pages
2 pages
publisher
Chemical and Biological Microsystems Society
conference name
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
conference location
Basel, Switzerland
conference dates
2019-10-27 - 2019-10-31
external identifiers
  • scopus:85094951173
ISBN
9781733419000
language
English
LU publication?
yes
id
8f6a520b-2211-4222-99c3-7b5d71a9f2e5
date added to LUP
2020-11-24 08:33:01
date last changed
2022-04-19 02:24:37
@inproceedings{8f6a520b-2211-4222-99c3-7b5d71a9f2e5,
  abstract     = {{<p>We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solvent distribution, and force application to create strong, leak-free bonds. The devices are evaluated for suitability for modelling biological barriers by culturing endothelial cells and measuring permeability using a plate reader.</p>}},
  author       = {{Persson, Henrik and Park, Siwan and Mohan, Michael and Young, Edmond and Simmons, Craig A.}},
  booktitle    = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}},
  isbn         = {{9781733419000}},
  keywords     = {{Laser cutting; Milling; Organ-on-a-chip; PET; PMMA; Solvent bonding; Thermoplastics}},
  language     = {{eng}},
  pages        = {{1666--1667}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  series       = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}},
  title        = {{Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices}},
  year         = {{2019}},
}