Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices
(2019) 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 p.1666-1667- Abstract
We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solvent distribution, and force application to create strong, leak-free bonds. The devices are evaluated for suitability for modelling biological barriers by culturing endothelial cells and measuring permeability using a plate reader.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8f6a520b-2211-4222-99c3-7b5d71a9f2e5
- author
- Persson, Henrik LU ; Park, Siwan ; Mohan, Michael ; Young, Edmond and Simmons, Craig A.
- organization
- publishing date
- 2019
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Laser cutting, Milling, Organ-on-a-chip, PET, PMMA, Solvent bonding, Thermoplastics
- host publication
- 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
- series title
- 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
- pages
- 2 pages
- publisher
- Chemical and Biological Microsystems Society
- conference name
- 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
- conference location
- Basel, Switzerland
- conference dates
- 2019-10-27 - 2019-10-31
- external identifiers
-
- scopus:85094951173
- ISBN
- 9781733419000
- language
- English
- LU publication?
- yes
- id
- 8f6a520b-2211-4222-99c3-7b5d71a9f2e5
- date added to LUP
- 2020-11-24 08:33:01
- date last changed
- 2022-04-19 02:24:37
@inproceedings{8f6a520b-2211-4222-99c3-7b5d71a9f2e5, abstract = {{<p>We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solvent distribution, and force application to create strong, leak-free bonds. The devices are evaluated for suitability for modelling biological barriers by culturing endothelial cells and measuring permeability using a plate reader.</p>}}, author = {{Persson, Henrik and Park, Siwan and Mohan, Michael and Young, Edmond and Simmons, Craig A.}}, booktitle = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}}, isbn = {{9781733419000}}, keywords = {{Laser cutting; Milling; Organ-on-a-chip; PET; PMMA; Solvent bonding; Thermoplastics}}, language = {{eng}}, pages = {{1666--1667}}, publisher = {{Chemical and Biological Microsystems Society}}, series = {{23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019}}, title = {{Rapid fabrication of PMMA/PET-E/PMMA for thermoplastic microfluidic membrane devices}}, year = {{2019}}, }