Non-lamellar lipid liquid crystalline structures at interfaces.
(2015) In Advances in Colloid and Interface Science 222(Online 15 November, 2014). p.135-147- Abstract
- The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in... (More)
- The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in biomedical devices for analyses and drug delivery, it is crucial to understand how they interact with and respond to different types of interfaces. Such non-lamellar interfacial layers can be used to entrap functional biomolecules that respond to lipid curvature as well as the confinement. It is also important to understand the structural changes of deposited lipid in relation to the corresponding bulk dispersions. They can be controlled by changing the lipid composition or by introducing components that can alter the curvature or by deposition on nano-structured surface, e.g. vertical nano-wire arrays. Progress in the area of liquid crystalline lipid based nanoparticles opens up new possibilities for the preparation of well-defined surface films with well-defined nano-structures. This review will focus on recent progress in the formation of non-lamellar dispersions and their interfacial properties at the solid/liquid and biologically relevant interfaces. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4913669
- author
- Chang, Debby LU ; Barauskas, Justas ; Dabkowska, Aleksandra LU ; Wadsäter, Maria LU ; Tiberg, Fredrik LU and Nylander, Tommy LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Advances in Colloid and Interface Science
- volume
- 222
- issue
- Online 15 November, 2014
- pages
- 135 - 147
- publisher
- Elsevier
- external identifiers
-
- pmid:25435157
- wos:000360416800012
- scopus:84938878218
- pmid:25435157
- ISSN
- 1873-3727
- DOI
- 10.1016/j.cis.2014.11.003
- language
- English
- LU publication?
- yes
- id
- 8fdb8324-9479-46cc-a0bf-3b199f51140f (old id 4913669)
- date added to LUP
- 2016-04-01 09:56:40
- date last changed
- 2022-03-04 06:31:38
@article{8fdb8324-9479-46cc-a0bf-3b199f51140f,
abstract = {{The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in biomedical devices for analyses and drug delivery, it is crucial to understand how they interact with and respond to different types of interfaces. Such non-lamellar interfacial layers can be used to entrap functional biomolecules that respond to lipid curvature as well as the confinement. It is also important to understand the structural changes of deposited lipid in relation to the corresponding bulk dispersions. They can be controlled by changing the lipid composition or by introducing components that can alter the curvature or by deposition on nano-structured surface, e.g. vertical nano-wire arrays. Progress in the area of liquid crystalline lipid based nanoparticles opens up new possibilities for the preparation of well-defined surface films with well-defined nano-structures. This review will focus on recent progress in the formation of non-lamellar dispersions and their interfacial properties at the solid/liquid and biologically relevant interfaces.}},
author = {{Chang, Debby and Barauskas, Justas and Dabkowska, Aleksandra and Wadsäter, Maria and Tiberg, Fredrik and Nylander, Tommy}},
issn = {{1873-3727}},
language = {{eng}},
number = {{Online 15 November, 2014}},
pages = {{135--147}},
publisher = {{Elsevier}},
series = {{Advances in Colloid and Interface Science}},
title = {{Non-lamellar lipid liquid crystalline structures at interfaces.}},
url = {{http://dx.doi.org/10.1016/j.cis.2014.11.003}},
doi = {{10.1016/j.cis.2014.11.003}},
volume = {{222}},
year = {{2015}},
}