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Tracking Parkinson's : Study Design and Baseline Patient Data

Malek, Naveed; Swallow, Diane M A; Grosset, Katherine A; Lawton, Michael A; Marrinan, Sarah L; Lehn, Alexander C; Bresner, Catherine; Bajaj, Nin; Barker, Roger A LU and Ben-Shlomo, Yoav, et al. (2015) In Journal of Parkinson's Disease 5(4). p.59-947
Abstract

BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.

OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.

METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset... (More)

BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.

OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.

METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.

RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).

CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.

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publication status
published
keywords
Adult, Age of Onset, Aged, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Parkinson Disease, Phenotype, Research Design, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
in
Journal of Parkinson's Disease
volume
5
issue
4
pages
13 pages
publisher
IOS Press
external identifiers
  • scopus:84952667395
ISSN
1877-718X
DOI
10.3233/JPD-150662
language
English
LU publication?
no
id
8fdcb1ff-c567-45b0-a063-7c971a3a5df9
date added to LUP
2016-11-23 13:28:15
date last changed
2017-06-18 05:00:21
@article{8fdcb1ff-c567-45b0-a063-7c971a3a5df9,
  abstract     = {<p>BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.</p><p>OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.</p><p>METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (&lt;3.5 years) and young onset (diagnosed &lt;50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.</p><p>RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).</p><p>CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.</p>},
  author       = {Malek, Naveed and Swallow, Diane M A and Grosset, Katherine A and Lawton, Michael A and Marrinan, Sarah L and Lehn, Alexander C and Bresner, Catherine and Bajaj, Nin and Barker, Roger A and Ben-Shlomo, Yoav and Burn, David J and Foltynie, Thomas and Hardy, John and Morris, Huw R and Williams, Nigel M and Wood, Nicholas and Grosset, Donald G and , },
  issn         = {1877-718X},
  keyword      = {Adult,Age of Onset,Aged,Female,Follow-Up Studies,Genotype,Humans,Male,Middle Aged,Parkinson Disease,Phenotype,Research Design,Journal Article,Multicenter Study,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {59--947},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Tracking Parkinson's : Study Design and Baseline Patient Data},
  url          = {http://dx.doi.org/10.3233/JPD-150662},
  volume       = {5},
  year         = {2015},
}