Tracking Parkinson's : Study Design and Baseline Patient Data
(2015) In Journal of Parkinson's Disease 5(4). p.59-947- Abstract
BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.
OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.
METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset... (More)
BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.
OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.
METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.
RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).
CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- keywords
- Adult, Age of Onset, Aged, Female, Follow-Up Studies, Genotype, Humans, Male, Middle Aged, Parkinson Disease, Phenotype, Research Design, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
- in
- Journal of Parkinson's Disease
- volume
- 5
- issue
- 4
- pages
- 13 pages
- publisher
- IOS Press
- external identifiers
-
- scopus:84952667395
- pmid:26485428
- ISSN
- 1877-718X
- DOI
- 10.3233/JPD-150662
- language
- English
- LU publication?
- no
- id
- 8fdcb1ff-c567-45b0-a063-7c971a3a5df9
- date added to LUP
- 2016-11-23 13:28:15
- date last changed
- 2024-06-28 19:40:03
@article{8fdcb1ff-c567-45b0-a063-7c971a3a5df9,
abstract = {{<p>BACKGROUND: There is wide variation in the phenotypic expression of Parkinson's disease (PD), which is driven by both genetic and epidemiological influences.</p><p>OBJECTIVES: To define and explain variation in the clinical phenotype of PD, in relation to genotypic variation.</p><p>METHODS: Tracking Parkinson's is a multicentre prospective longitudinal epidemiologic and biomarker study of PD. Patients attending specialist clinics in the United Kingdom with recent onset (<3.5 years) and young onset (diagnosed <50 years of age) PD were enrolled. Motor, non-motor and quality of life assessments were performed using validated scales. Cases are followed up 6 monthly up to 4.5 years for recent onset PD, and up to 1 year for young onset PD. We present here baseline clinical data from this large and demographically representative cohort.</p><p>RESULTS: 2247 PD cases were recruited (1987 recent onset, 260 young onset). Recent onset cases had a mean (standard deviation, SD) age of 67.6 years (9.3) at study entry, 65.7% males, with disease duration 1.3 years (0.9), MDS-UPDRS 3 scores 22.9 (12.3), LEDD 295 mg/day (211) and PDQ-8 score 5.9 (4.8). Young onset cases were 53.5 years old (7.8) at study entry, 66.9% male, with disease duration 10.2 years (6.7), MDS-UPDRS 3 scores 27.4 (15.3), LEDD 926 mg/day (567) and PDQ-8 score 11.6 (6.1).</p><p>CONCLUSIONS: We have established a large clinical PD cohort, consisting of young onset and recent onset cases, which is designed to evaluate variation in clinical expression, in relation to genetic influences, and which offers a platform for future imaging and biomarker research.</p>}},
author = {{Malek, Naveed and Swallow, Diane M A and Grosset, Katherine A and Lawton, Michael A and Marrinan, Sarah L and Lehn, Alexander C and Bresner, Catherine and Bajaj, Nin and Barker, Roger A and Ben-Shlomo, Yoav and Burn, David J and Foltynie, Thomas and Hardy, John and Morris, Huw R and Williams, Nigel M and Wood, Nicholas and Grosset, Donald G}},
issn = {{1877-718X}},
keywords = {{Adult; Age of Onset; Aged; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Parkinson Disease; Phenotype; Research Design; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{4}},
pages = {{59--947}},
publisher = {{IOS Press}},
series = {{Journal of Parkinson's Disease}},
title = {{Tracking Parkinson's : Study Design and Baseline Patient Data}},
url = {{http://dx.doi.org/10.3233/JPD-150662}},
doi = {{10.3233/JPD-150662}},
volume = {{5}},
year = {{2015}},
}