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Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy

Nayak, RC; Agardh, Carl-David LU ; Kwok, MGK; Stjernquist, Håkan LU ; Farthing-Nayak, PJ and Agardh, Elisabet LU (2003) In Diabetologia 46(4). p.511-513
Abstract
Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades... (More)
Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p<0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p<0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
capillaries, retinal diseases, autommunity, diabetic retinopathy, pericytes, diabetes mellitus
in
Diabetologia
volume
46
issue
4
pages
511 - 513
publisher
Springer Verlag
external identifiers
  • wos:000183198600010
  • pmid:12739023
  • scopus:0038632185
ISSN
1432-0428
DOI
10.1007/s00125-003-1057-0
language
English
LU publication?
yes
id
cef64cef-d1a0-4fef-b23e-d5962c820cc9 (old id 900368)
date added to LUP
2008-01-15 09:04:06
date last changed
2018-01-07 06:09:21
@article{cef64cef-d1a0-4fef-b23e-d5962c820cc9,
  abstract     = {Aims/Hypothesis. This study aims to determine the prevalence of anti-pericyte autoantibodies in Type 2 diabetes and to characterize these autoantibodies as new markers of disease activity in diabetic retinopathy. Methods. A total of 299 patients with Type 2 diabetes participated in this study. Retinopathy was assessed by 7-field stereo fundus photography and was graded according to the ETDRS scale. Serum anti-pericyte autoantibodies were detected by immunofluorescence on tissue cultured bovine retinal pericytes. Results. The prevalence of anti-pericyte autoantibodies in Type 2 diabetic patients was 54% and was approximately equal in men and women. The prevalence was approximately 55% with retinopathy at grades from 10 to 53. At grades above 53 the prevalence declined to 23% (p&lt;0.0001). The highest prevalence by duration of diabetes, 70%, was found at 0 to 5 years and the lowest, 25% at more than 25 years duration (p&lt;0.0001). Conclusion/interpretation. Anti-pericyte autoantibodies are present at high prevalence in Type 2 diabetes. Their presence during earlier stages of retinopathy could be due to a reaction with antigens expressed by "activated" pericytes. The decline in antibody prevalence in advanced retinopathy could mark pericyte loss and progression to an angiogenic retinal milieu.},
  author       = {Nayak, RC and Agardh, Carl-David and Kwok, MGK and Stjernquist, Håkan and Farthing-Nayak, PJ and Agardh, Elisabet},
  issn         = {1432-0428},
  keyword      = {capillaries,retinal diseases,autommunity,diabetic retinopathy,pericytes,diabetes mellitus},
  language     = {eng},
  number       = {4},
  pages        = {511--513},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy},
  url          = {http://dx.doi.org/10.1007/s00125-003-1057-0},
  volume       = {46},
  year         = {2003},
}