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Increased frequency of a new polymorphism in the cycle 2 (cdc2) gene in patients with Alzheimer's disease frontotemporal dementia

Johansson, A; Hampel, H; Faltraco, F; Buerger, K; Minthon, Lennart LU ; Bogdanovic, N; Sjogren, M; Zetterberg, H; Forsell, L and Lilius, L, et al. (2003) In Neuroscience Letters 340(1). p.69-73
Abstract
Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6 + 7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6 +... (More)
Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6 + 7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6 + 7II genotype. Our findings suggest that the Ex6 + 7I allele is associated with tauopathies, both AD and FrD. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. (Less)
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subject
keywords
Alzheimer's disease, senile plaques, apolipoprotein E, frontotemporal dementia, cdc2
in
Neuroscience Letters
volume
340
issue
1
pages
69 - 73
publisher
Elsevier
external identifiers
  • pmid:12648761
  • wos:000181901700018
  • scopus:0344837798
ISSN
0304-3940
DOI
language
English
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yes
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2ffdbb68-276f-4562-bd35-f21426326a9b (old id 900524)
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2008-01-14 14:53:44
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2018-05-29 11:14:57
@article{2ffdbb68-276f-4562-bd35-f21426326a9b,
  abstract     = {Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6 + 7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6 + 7II genotype. Our findings suggest that the Ex6 + 7I allele is associated with tauopathies, both AD and FrD. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.},
  author       = {Johansson, A and Hampel, H and Faltraco, F and Buerger, K and Minthon, Lennart and Bogdanovic, N and Sjogren, M and Zetterberg, H and Forsell, L and Lilius, L and Wahlund, LO and Rymo, L and Prince, JA and Blennow, K},
  issn         = {0304-3940},
  keyword      = {Alzheimer's disease,senile plaques,apolipoprotein E,frontotemporal dementia,cdc2},
  language     = {eng},
  number       = {1},
  pages        = {69--73},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Increased frequency of a new polymorphism in the cycle 2 (cdc2) gene in patients with Alzheimer's disease frontotemporal dementia},
  url          = {http://dx.doi.org/},
  volume       = {340},
  year         = {2003},
}