Cationic Polymer Brushes Functionalized with Carbon Dots and Boronic Acids for Bacterial Detection and Inactivation
Zhang, Qicheng LU ; Chen, Si LU ; Xue, Xiaoting LU ; Hajizadeh, Solmaz LU
; Yamazaki, Tomohiko
and Ye, Lei
LU
(2025)
In ACS Omega
10(14).
p.14536-14546
- Abstract
- Drug-resistant bacterial infections are among the most severe physiological challenges facing human health. Therefore, the detection and inactivation of pathogenic bacteria remains a crucial therapeutic goal in modern society. In this study, we design multifunctional nanocomposites aimed at bacterial binding, fluorescence labeling, and synergistic antibacterial treatment. These nanocomposites are prepared by introducing cationic polymers with quaternary ammonium compounds onto silica nanoparticles using surface-initiated atom transfer radical polymerization, followed by incorporation of copper-doped carbon dots and modification of boronic acid. The cationic polymer units and boronic acid end groups enhance the bacterial binding capacity... (More)
- Drug-resistant bacterial infections are among the most severe physiological challenges facing human health. Therefore, the detection and inactivation of pathogenic bacteria remains a crucial therapeutic goal in modern society. In this study, we design multifunctional nanocomposites aimed at bacterial binding, fluorescence labeling, and synergistic antibacterial treatment. These nanocomposites are prepared by introducing cationic polymers with quaternary ammonium compounds onto silica nanoparticles using surface-initiated atom transfer radical polymerization, followed by incorporation of copper-doped carbon dots and modification of boronic acid. The cationic polymer units and boronic acid end groups enhance the bacterial binding capacity and synergistic bactericidal effects in cooperation with the carbon dots. Due to the stable fluorescent properties of carbon dots, the nanocomposites can generate fluorescence signals around bacteria, enabling bacterial fluorescence imaging. Overall, this study demonstrates a multifunctional nanocomposite-assisted strategy for bacterial labeling, imaging, and deactivation, providing a novel approach for bacterial detection and synergistic treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/909e8ead-5c80-4cd0-ae25-21ceef112c7c
- author
- Zhang, Qicheng
LU
; Chen, Si
LU
; Xue, Xiaoting
LU
; Hajizadeh, Solmaz
LU
; Yamazaki, Tomohiko
and Ye, Lei
LU
- organization
- publishing date
- 2025-04-02
- type
- Contribution to journal
- publication status
- published
- subject
- in
- ACS Omega
- volume
- 10
- issue
- 14
- pages
- 11 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:40256518
- scopus:105002680880
- ISSN
- 2470-1343
- DOI
- 10.1021/acsomega.5c01507
- language
- English
- LU publication?
- yes
- id
- 909e8ead-5c80-4cd0-ae25-21ceef112c7c
- date added to LUP
- 2025-05-23 02:40:56
- date last changed
- 2025-05-23 11:18:45
@article{909e8ead-5c80-4cd0-ae25-21ceef112c7c,
abstract = {{Drug-resistant bacterial infections are among the most severe physiological challenges facing human health. Therefore, the detection and inactivation of pathogenic bacteria remains a crucial therapeutic goal in modern society. In this study, we design multifunctional nanocomposites aimed at bacterial binding, fluorescence labeling, and synergistic antibacterial treatment. These nanocomposites are prepared by introducing cationic polymers with quaternary ammonium compounds onto silica nanoparticles using surface-initiated atom transfer radical polymerization, followed by incorporation of copper-doped carbon dots and modification of boronic acid. The cationic polymer units and boronic acid end groups enhance the bacterial binding capacity and synergistic bactericidal effects in cooperation with the carbon dots. Due to the stable fluorescent properties of carbon dots, the nanocomposites can generate fluorescence signals around bacteria, enabling bacterial fluorescence imaging. Overall, this study demonstrates a multifunctional nanocomposite-assisted strategy for bacterial labeling, imaging, and deactivation, providing a novel approach for bacterial detection and synergistic treatment.}},
author = {{Zhang, Qicheng and Chen, Si and Xue, Xiaoting and Hajizadeh, Solmaz and Yamazaki, Tomohiko and Ye, Lei}},
issn = {{2470-1343}},
language = {{eng}},
month = {{04}},
number = {{14}},
pages = {{14536--14546}},
publisher = {{The American Chemical Society (ACS)}},
series = {{ACS Omega}},
title = {{Cationic Polymer Brushes Functionalized with Carbon Dots and Boronic Acids for Bacterial Detection and Inactivation}},
url = {{http://dx.doi.org/10.1021/acsomega.5c01507}},
doi = {{10.1021/acsomega.5c01507}},
volume = {{10}},
year = {{2025}},
}