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National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity

Lundgren, Pia ; Morsing, Eva LU ; Hård, Anna Lena ; Rakow, Alexander ; Hellström-Westas, Lena LU ; Jacobson, Lena ; Johnson, Mats ; Holmström, Gerd ; Nilsson, Staffan and Smith, Lois E. , et al. (2022) In Acta Paediatrica, International Journal of Paediatrics 111(8). p.1515-1525
Abstract

Aim: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period. Methods: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. Results: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were... (More)

Aim: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period. Methods: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. Results: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p < 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. Conclusion: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long-term outcome.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
extremely preterm, necrotising enterocolitis, neonatal morbidities, proactive approach, survival rates
in
Acta Paediatrica, International Journal of Paediatrics
volume
111
issue
8
pages
1515 - 1525
publisher
Wiley-Blackwell
external identifiers
  • pmid:35395120
  • scopus:85128070235
ISSN
0803-5253
DOI
10.1111/apa.16354
language
English
LU publication?
yes
id
9123d26f-d6b3-415e-8c89-0898fefd9d75
date added to LUP
2022-06-16 15:02:39
date last changed
2024-04-18 10:28:13
@article{9123d26f-d6b3-415e-8c89-0898fefd9d75,
  abstract     = {{<p>Aim: To describe survival and neonatal morbidities in infants born before 24 weeks of gestation during a 12-year period. Methods: Data were retrieved from national registries and validated in medical files of infants born before 24 weeks of gestation 2007–2018 in Sweden. Temporal changes were evaluated. Results: In 2007–2018, 282 live births were recorded at 22 weeks and 460 at 23 weeks of gestation. Survival to discharge from hospital of infants born alive at 22 and 23 weeks increased from 20% to 38% (p = 0.006) and from 45% to 67% (p &lt; 0.001) respectively. Caesarean section increased from 12% to 22% (p = 0.038) for infants born at 22 weeks. Neonatal morbidity rates in infants alive at 40 weeks of postmenstrual age (n = 399) were unchanged except for an increase in necrotising enterocolitis from 0 to 33% (p = 0.017) in infants born at 22 weeks of gestation. Bronchopulmonary dysplasia was more common in boys than girls, 90% versus 82% (p = 0.044). The number of infants surviving to 40 weeks doubled over time. Conclusion: Increased survival of infants born before 24 weeks of gestation resulted in increasing numbers of very immature infants with severe neonatal morbidities likely to have a negative impact on long-term outcome.</p>}},
  author       = {{Lundgren, Pia and Morsing, Eva and Hård, Anna Lena and Rakow, Alexander and Hellström-Westas, Lena and Jacobson, Lena and Johnson, Mats and Holmström, Gerd and Nilsson, Staffan and Smith, Lois E. and Sävman, Karin and Hellström, Ann}},
  issn         = {{0803-5253}},
  keywords     = {{extremely preterm; necrotising enterocolitis; neonatal morbidities; proactive approach; survival rates}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1515--1525}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity}},
  url          = {{http://dx.doi.org/10.1111/apa.16354}},
  doi          = {{10.1111/apa.16354}},
  volume       = {{111}},
  year         = {{2022}},
}