Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Image-based non-invasive assessment of suction blister wounds for clinical safety and efficacy

Wallblom, Karl LU orcid ; Lundgren, Sigrid LU ; Saleh, Karim LU ; Schmidtchen, Artur LU and Puthia, Manoj LU (2024) In Wound Repair and Regeneration
Abstract

Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness. We employed this methodology on 16 suction blister wounds used as controls in a clinical phase-1... (More)

Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness. We employed this methodology on 16 suction blister wounds used as controls in a clinical phase-1 trial. Our method enabled us to discern and quantify subtle differences between individual wounds concerning healing progress, erythema and wound exudation. The wound healing score exhibited a high inter-rater agreement. There was a robust correlation between the spectrophotometer-measured erythema index and photography-based wound redness, as well as between dressing protein content and photography-based dressing yellowness. In conclusion, this study equips researchers conducting clinical wound studies with reproducible methods that may support future wound research and aid in the development of new treatments.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
clinical photography, clinical studies, clinical trial, imaging, wound healing
in
Wound Repair and Regeneration
publisher
Wiley-Blackwell
external identifiers
  • pmid:38511666
  • scopus:85188818356
ISSN
1067-1927
DOI
10.1111/wrr.13172
language
English
LU publication?
yes
id
91627d1c-3e1e-4a20-bad0-9ec001fba3e1
date added to LUP
2024-04-16 12:32:18
date last changed
2024-04-16 12:33:31
@article{91627d1c-3e1e-4a20-bad0-9ec001fba3e1,
  abstract     = {{<p>Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wound model. Our method encompasses a protocol for capturing consistent, high-quality photographs and procedures for quantifying these images via a visual wound healing score and a computer-assisted colour analysis of wound exudation and wound redness. We employed this methodology on 16 suction blister wounds used as controls in a clinical phase-1 trial. Our method enabled us to discern and quantify subtle differences between individual wounds concerning healing progress, erythema and wound exudation. The wound healing score exhibited a high inter-rater agreement. There was a robust correlation between the spectrophotometer-measured erythema index and photography-based wound redness, as well as between dressing protein content and photography-based dressing yellowness. In conclusion, this study equips researchers conducting clinical wound studies with reproducible methods that may support future wound research and aid in the development of new treatments.</p>}},
  author       = {{Wallblom, Karl and Lundgren, Sigrid and Saleh, Karim and Schmidtchen, Artur and Puthia, Manoj}},
  issn         = {{1067-1927}},
  keywords     = {{clinical photography; clinical studies; clinical trial; imaging; wound healing}},
  language     = {{eng}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Wound Repair and Regeneration}},
  title        = {{Image-based non-invasive assessment of suction blister wounds for clinical safety and efficacy}},
  url          = {{http://dx.doi.org/10.1111/wrr.13172}},
  doi          = {{10.1111/wrr.13172}},
  year         = {{2024}},
}