Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art - review article
(2008) 24th Congress of the Polish-Physiological-Society 59. p.91-106- Abstract
- The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of... (More)
- The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of paramount importance include impaired bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1285706
- author
- Harrison, A. P. and Pierzynowski, Stefan LU
- organization
- publishing date
- 2008
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- 2-oxoglutarate, osteoporoses, melatonin, cholesterol, cancer, collagen, muscle, artery elasticity, absorption, mineral, alpha keto glutarate (AKG)
- host publication
- JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- volume
- 59
- pages
- 91 - 106
- publisher
- Polish Physiological Society
- conference name
- 24th Congress of the Polish-Physiological-Society
- conference dates
- 2008-09-11 - 2008-09-13
- external identifiers
-
- wos:000259923400005
- scopus:51349147548
- ISSN
- 0867-5910
- language
- English
- LU publication?
- yes
- id
- 91a711d0-fa97-4621-a4fe-6868b90c96be (old id 1285706)
- date added to LUP
- 2016-04-01 13:49:37
- date last changed
- 2022-04-21 23:48:45
@inproceedings{91a711d0-fa97-4621-a4fe-6868b90c96be,
abstract = {{The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, Such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation, The topics of paramount importance include impaired bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.}},
author = {{Harrison, A. P. and Pierzynowski, Stefan}},
booktitle = {{JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY}},
issn = {{0867-5910}},
keywords = {{2-oxoglutarate; osteoporoses; melatonin; cholesterol; cancer; collagen; muscle; artery elasticity; absorption; mineral; alpha keto glutarate (AKG)}},
language = {{eng}},
pages = {{91--106}},
publisher = {{Polish Physiological Society}},
title = {{Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption/metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art - review article}},
volume = {{59}},
year = {{2008}},
}