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Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.

Engfeldt, Malin LU ; Zimerson, Erik LU ; Karlsson, Daniel ; Skarping, Gunnar LU ; Isaksson, Marléne LU and Bruze, Magnus LU (2007) In Contact Dermatitis 56(1). p.27-34
Abstract
We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a... (More)
We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAS 9016-87-9, contact dermatitis, CAS 101-68-8, stability, polyurethane, polymeric MDI, PMDI, patch, test preparation, diphenylmethane-4
in
Contact Dermatitis
volume
56
issue
1
pages
27 - 34
publisher
Wiley-Blackwell
external identifiers
  • scopus:33845543893
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.01007.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Occupational and Environmental Dermatology Unit (013241310), Division of Occupational and Environmental Medicine (013078001)
id
91d1f30f-e1eb-4b94-a4f6-f99637fabf42 (old id 163916)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17177706&dopt=Abstract
date added to LUP
2016-04-01 12:27:07
date last changed
2022-08-06 18:28:32
@article{91d1f30f-e1eb-4b94-a4f6-f99637fabf42,
  abstract     = {{We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers.}},
  author       = {{Engfeldt, Malin and Zimerson, Erik and Karlsson, Daniel and Skarping, Gunnar and Isaksson, Marléne and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{CAS 9016-87-9; contact dermatitis; CAS 101-68-8; stability; polyurethane; polymeric MDI; PMDI; patch; test preparation; diphenylmethane-4}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{27--34}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0536.2007.01007.x}},
  doi          = {{10.1111/j.1600-0536.2007.01007.x}},
  volume       = {{56}},
  year         = {{2007}},
}