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Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : Results from the EPIC cohort

Idahl, Annika ; Le Cornet, Charlotte ; González Maldonado, Sandra ; Waterboer, Tim ; Bender, Noemi ; Tjønneland, Anne ; Hansen, Louise ; Boutron-Ruault, Marie Christine ; Fournier, Agnès and Kvaskoff, Marina , et al. (2020) In International Journal of Cancer 147(8). p.2042-2052
Abstract

A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex... (More)

A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chlamydia trachomatis, herpes simplex virus, human papillomavirus, Mycoplasma genitalium, ovarian cancer
in
International Journal of Cancer
volume
147
issue
8
pages
11 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:32243586
  • scopus:85084079478
ISSN
0020-7136
DOI
10.1002/ijc.32999
language
English
LU publication?
yes
id
91ffa7c1-1a80-43a0-9c3d-c560ebee1328
date added to LUP
2020-06-04 15:08:20
date last changed
2024-04-17 09:20:40
@article{91ffa7c1-1a80-43a0-9c3d-c560ebee1328,
  abstract     = {{<p>A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.</p>}},
  author       = {{Idahl, Annika and Le Cornet, Charlotte and González Maldonado, Sandra and Waterboer, Tim and Bender, Noemi and Tjønneland, Anne and Hansen, Louise and Boutron-Ruault, Marie Christine and Fournier, Agnès and Kvaskoff, Marina and Boeing, Heiner and Trichopoulou, Antonia and Valanou, Elisavet and Peppa, Eleni and Palli, Domenico and Agnoli, Claudia and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Onland-Moret, N. Charlotte and Gram, Inger T. and Weiderpass, Elisabete and Quirós, Jose R. and Duell, Eric J. and Sánchez, Maria Jose and Chirlaque, Maria Dolores and Barricarte, Aurelio and Gil, Leire and Brändstedt, Jenny and Riesbeck, Kristian and Lundin, Eva and Khaw, Kay Tee and Perez-Cornago, Aurora and Gunter, Marc J. and Dossus, Laure and Kaaks, Rudolf and Fortner, Renée T.}},
  issn         = {{0020-7136}},
  keywords     = {{Chlamydia trachomatis; herpes simplex virus; human papillomavirus; Mycoplasma genitalium; ovarian cancer}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{8}},
  pages        = {{2042--2052}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : Results from the EPIC cohort}},
  url          = {{http://dx.doi.org/10.1002/ijc.32999}},
  doi          = {{10.1002/ijc.32999}},
  volume       = {{147}},
  year         = {{2020}},
}