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Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death

Petersén, Åsa LU ; Larsen, K E ; Behr, G G ; Romero, N ; Przedborski, S ; Brundin, Patrik LU and Sulzer, D (2001) In Brain Research Bulletin 56(3-4). p.331-335
Abstract
In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Huntington’s disease, Autophagy, DARPP-32, Medium spiny neuron
in
Brain Research Bulletin
volume
56
issue
3-4
pages
331 - 335
publisher
Elsevier
external identifiers
  • pmid:11719268
  • scopus:0035503713
ISSN
0361-9230
DOI
10.1016/S0361-9230(01)00580-9
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Translational Neuroendocrinology (013210010)
id
921b92bc-20a5-40a9-a0b6-33570ff34050 (old id 1121754)
date added to LUP
2016-04-01 11:39:11
date last changed
2022-01-26 08:11:16
@article{921b92bc-20a5-40a9-a0b6-33570ff34050,
  abstract     = {{In hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) protects striatal neurons against a variety of insults. We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular oxyradical stress triggered by dopamine, and partially blocked basal and dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons from dopamine-induced cell death. Therefore, BDNF inhibits free radical and apoptotic pathways in medium spiny neurons, but does so downstream from the point of commitment to cell death.}},
  author       = {{Petersén, Åsa and Larsen, K E and Behr, G G and Romero, N and Przedborski, S and Brundin, Patrik and Sulzer, D}},
  issn         = {{0361-9230}},
  keywords     = {{Huntington’s disease; Autophagy; DARPP-32; Medium spiny neuron}},
  language     = {{eng}},
  number       = {{3-4}},
  pages        = {{331--335}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research Bulletin}},
  title        = {{Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death}},
  url          = {{http://dx.doi.org/10.1016/S0361-9230(01)00580-9}},
  doi          = {{10.1016/S0361-9230(01)00580-9}},
  volume       = {{56}},
  year         = {{2001}},
}