Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival
(2022) In Nutrients 14(16).- Abstract
Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared... (More)
Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.
(Less)
- author
- Huss, Linnea LU ; Butt, Salma Tunå LU ; Borgquist, Signe LU ; Elebro, Karin LU ; Sandsveden, Malte LU ; Manjer, Jonas LU and Rosendahl, Ann LU
- organization
- publishing date
- 2022-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, incidence, survival, vitamin D, vitamin D receptor
- in
- Nutrients
- volume
- 14
- issue
- 16
- article number
- 3353
- publisher
- MDPI AG
- external identifiers
-
- scopus:85137384093
- pmid:36014861
- ISSN
- 2072-6643
- DOI
- 10.3390/nu14163353
- language
- English
- LU publication?
- yes
- id
- 922bbe98-48d3-4410-aab7-dfb6ea391424
- date added to LUP
- 2022-11-23 10:37:57
- date last changed
- 2024-09-19 08:36:47
@article{922bbe98-48d3-4410-aab7-dfb6ea391424, abstract = {{<p>Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.</p>}}, author = {{Huss, Linnea and Butt, Salma Tunå and Borgquist, Signe and Elebro, Karin and Sandsveden, Malte and Manjer, Jonas and Rosendahl, Ann}}, issn = {{2072-6643}}, keywords = {{breast cancer; incidence; survival; vitamin D; vitamin D receptor}}, language = {{eng}}, month = {{08}}, number = {{16}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival}}, url = {{http://dx.doi.org/10.3390/nu14163353}}, doi = {{10.3390/nu14163353}}, volume = {{14}}, year = {{2022}}, }