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Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival

Huss, Linnea LU ; Butt, Salma Tunå LU ; Borgquist, Signe LU ; Elebro, Karin LU ; Sandsveden, Malte LU ; Manjer, Jonas LU and Rosendahl, Ann LU (2022) In Nutrients 14(16).
Abstract

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared... (More)

Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, incidence, survival, vitamin D, vitamin D receptor
in
Nutrients
volume
14
issue
16
article number
3353
publisher
MDPI AG
external identifiers
  • pmid:36014861
  • scopus:85137384093
ISSN
2072-6643
DOI
10.3390/nu14163353
language
English
LU publication?
yes
id
922bbe98-48d3-4410-aab7-dfb6ea391424
date added to LUP
2022-11-23 10:37:57
date last changed
2024-05-01 19:21:33
@article{922bbe98-48d3-4410-aab7-dfb6ea391424,
  abstract     = {{<p>Previous research suggests associations between low systemic levels of vitamin D and poor breast cancer prognosis and between expression of the vitamin D receptor (VDR) in breast cancers and survival. This study aimed to study associations between pre-diagnostic systemic levels of vitamin D and expression of VDR in subsequent breast tumors, and interactions between vitamin D and VDR on breast cancer mortality. Systemic vitamin D levels were measured in women within the Malmö Diet and Cancer Study. The expression of VDR was evaluated immunohistochemically in a tissue microarray of subsequent breast cancers. Statistical analyses followed. Women with high levels of vitamin D had a smaller proportion of VDR negative breast tumors compared to women with low levels of vitamin D (odds ratio: 0.68; 95% confidence interval: 0.41–1.13). Vitamin D levels were not found to modify the association between low VDR expression and high breast cancer mortality. To conclude, there was no statistical evidence for an association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality. Further studies are needed in order to establish the effects of vitamin D on breast cancer.</p>}},
  author       = {{Huss, Linnea and Butt, Salma Tunå and Borgquist, Signe and Elebro, Karin and Sandsveden, Malte and Manjer, Jonas and Rosendahl, Ann}},
  issn         = {{2072-6643}},
  keywords     = {{breast cancer; incidence; survival; vitamin D; vitamin D receptor}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{16}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Levels of Vitamin D and Expression of the Vitamin D Receptor in Relation to Breast Cancer Risk and Survival}},
  url          = {{http://dx.doi.org/10.3390/nu14163353}},
  doi          = {{10.3390/nu14163353}},
  volume       = {{14}},
  year         = {{2022}},
}