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Impact of postoperative complications and type 2 diabetes on breast cancer recurrence and mortality

Kjærgaard, Kasper A. ; Christiansen, Peer ; Borgquist, Signe LU and Cronin-Fenton, Deirdre (2025) In British Journal of Surgery 112(8).
Abstract

Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with incident early-stage breast cancer diagnosed 1996–2017 was assembled. All women underwent mastectomy or breast-conserving surgery. Using diagnostic codes, systemic and surgical-site complications within 30 days of surgery were defined. Early recurrence (<10 years from diagnosis) was ascertained from the DBCG and late recurrence (≥10 years... (More)

Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with incident early-stage breast cancer diagnosed 1996–2017 was assembled. All women underwent mastectomy or breast-conserving surgery. Using diagnostic codes, systemic and surgical-site complications within 30 days of surgery were defined. Early recurrence (<10 years from diagnosis) was ascertained from the DBCG and late recurrence (≥10 years after diagnosis) via a validated registry-based algorithm. Incidence rates (IRs) per 1000 person-years were calculated, and Cox regression was used to estimate adjusted hazard ratios (aHRs) of early and late recurrence, and death, according to postoperative complications. Potential effect measure modification by T2D was evaluated. Results: Among 58 198 women undergoing breast cancer surgery, 6285 (10.8%) had postoperative complications. Overall, 747 and 5756 women with and without complications developed early recurrence (IR: 19.7 and 17.9, aHR = 1.04, 95% c.i. 0.96, 1.13), whereas 314 and 3314 women developed late recurrence (IR: 23.9 and 26.0, and aHR = 0.90, 95% c.i. 0.80, 1.02). Prevalent T2D did not impact these findings. Women with postoperative complications had higher mortality rates than those without complications (aHR = 1.11; 95% c.i. 1.06, 1.16); especially those with T2D versus no T2D (aHR = 1.50; 95% c.i. 1.30, 1.73). Conclusion: Postoperative complications after breast cancer primary surgery did not impact recurrence risk but had a negative impact on survival, especially in women with T2D.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Surgery
volume
112
issue
8
article number
znaf176
publisher
Oxford University Press
external identifiers
  • scopus:105013846311
  • pmid:40847759
ISSN
0007-1323
DOI
10.1093/bjs/znaf176
language
English
LU publication?
yes
id
923eac41-6ef3-4180-aa25-36592217d782
date added to LUP
2025-11-07 11:01:16
date last changed
2025-11-08 03:00:02
@article{923eac41-6ef3-4180-aa25-36592217d782,
  abstract     = {{<p>Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with incident early-stage breast cancer diagnosed 1996–2017 was assembled. All women underwent mastectomy or breast-conserving surgery. Using diagnostic codes, systemic and surgical-site complications within 30 days of surgery were defined. Early recurrence (&lt;10 years from diagnosis) was ascertained from the DBCG and late recurrence (≥10 years after diagnosis) via a validated registry-based algorithm. Incidence rates (IRs) per 1000 person-years were calculated, and Cox regression was used to estimate adjusted hazard ratios (aHRs) of early and late recurrence, and death, according to postoperative complications. Potential effect measure modification by T2D was evaluated. Results: Among 58 198 women undergoing breast cancer surgery, 6285 (10.8%) had postoperative complications. Overall, 747 and 5756 women with and without complications developed early recurrence (IR: 19.7 and 17.9, aHR = 1.04, 95% c.i. 0.96, 1.13), whereas 314 and 3314 women developed late recurrence (IR: 23.9 and 26.0, and aHR = 0.90, 95% c.i. 0.80, 1.02). Prevalent T2D did not impact these findings. Women with postoperative complications had higher mortality rates than those without complications (aHR = 1.11; 95% c.i. 1.06, 1.16); especially those with T2D versus no T2D (aHR = 1.50; 95% c.i. 1.30, 1.73). Conclusion: Postoperative complications after breast cancer primary surgery did not impact recurrence risk but had a negative impact on survival, especially in women with T2D.</p>}},
  author       = {{Kjærgaard, Kasper A. and Christiansen, Peer and Borgquist, Signe and Cronin-Fenton, Deirdre}},
  issn         = {{0007-1323}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{Oxford University Press}},
  series       = {{British Journal of Surgery}},
  title        = {{Impact of postoperative complications and type 2 diabetes on breast cancer recurrence and mortality}},
  url          = {{http://dx.doi.org/10.1093/bjs/znaf176}},
  doi          = {{10.1093/bjs/znaf176}},
  volume       = {{112}},
  year         = {{2025}},
}