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Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity

Bemark, Mats LU orcid ; Pitcher, Michael J ; Dionisi, Chiara and Spencer, Jo (2024) In Trends in Immunology
Abstract

The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that... (More)

The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that identify GALT as distinctive, and able to support these processes.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Trends in Immunology
publisher
Elsevier
external identifiers
  • scopus:85186253060
  • pmid:38402045
ISSN
1471-4981
DOI
10.1016/j.it.2024.01.006
language
English
LU publication?
yes
additional info
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
id
92601127-23ba-4e00-98e9-d902e81013da
date added to LUP
2024-02-27 18:31:15
date last changed
2024-04-22 21:37:24
@article{92601127-23ba-4e00-98e9-d902e81013da,
  abstract     = {{<p>The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that identify GALT as distinctive, and able to support these processes.</p>}},
  author       = {{Bemark, Mats and Pitcher, Michael J and Dionisi, Chiara and Spencer, Jo}},
  issn         = {{1471-4981}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Immunology}},
  title        = {{Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity}},
  url          = {{http://dx.doi.org/10.1016/j.it.2024.01.006}},
  doi          = {{10.1016/j.it.2024.01.006}},
  year         = {{2024}},
}