Mucosal exudation of plasma is a noninjurious intestinal defense mechanism
(1993) In Allergy 48(8). p.581-586- Abstract
- We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107656
- author
- Persson, C G ; Gustafsson, B ; Erjefält, Jonas LU and Sundler, Frank LU
- organization
- publishing date
- 1993
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- endointestinal allergen challenge, epithelial integrity, luminal entry of plasma, mucosal exudation
- in
- Allergy
- volume
- 48
- issue
- 8
- pages
- 581 - 586
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:8116857
- scopus:0027436575
- ISSN
- 1398-9995
- DOI
- 10.1111/j.1398-9995.1993.tb00752.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Airway Inflammation and Immunology (013212038)
- id
- 926bab1e-4245-4054-97c8-f37eee147031 (old id 1107656)
- date added to LUP
- 2016-04-01 16:44:36
- date last changed
- 2021-08-29 05:19:21
@article{926bab1e-4245-4054-97c8-f37eee147031, abstract = {{We have demonstrated in sensitized rats that the immediate response to endointestinal challenge with allergen (10(-6) M ovalbumin) is characterized by mucosal exudation of plasma with little or no concomitant change in the mucosal absorption capacity. The luminal entry of plasma macromolecules also leaves the light microscopic structure and the ultrastructure of the mucosa unaffected. It is possible that the plasticity of epithelial zonulae occludens allows a noninjurious and unidirectional paracellular flux of extravasated plasma into the gut lumen. We propose that inflammatory-stimulus-induced mucosal exudation of plasma belongs to the first-line defense mechanisms of the intact lining of the intestine.}}, author = {{Persson, C G and Gustafsson, B and Erjefält, Jonas and Sundler, Frank}}, issn = {{1398-9995}}, keywords = {{endointestinal allergen challenge; epithelial integrity; luminal entry of plasma; mucosal exudation}}, language = {{eng}}, number = {{8}}, pages = {{581--586}}, publisher = {{Wiley-Blackwell}}, series = {{Allergy}}, title = {{Mucosal exudation of plasma is a noninjurious intestinal defense mechanism}}, url = {{http://dx.doi.org/10.1111/j.1398-9995.1993.tb00752.x}}, doi = {{10.1111/j.1398-9995.1993.tb00752.x}}, volume = {{48}}, year = {{1993}}, }