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Treatment of rat glioma with electrochemotherapy

Salford, L G LU ; Engström, P LU and Persson, B R LU (2000) In Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery 37. p.7-313
Abstract

The first attempt to apply electrochemotherapy (ECT) to the brain was reported in 1993 by Salford et al. 1993 (1). They managed to significantly prolong the survival of RG2 glioma bearing Fischer-344 rats by 200% by iv administration of bleomycin followed by intracranial electrochemotherapy with exponential decaying pulses. In collaboration with the department of tumor immunology, Lund University, an ethyl-nitroso-urea induced rat glioma cell line (N32) is developed that produces glioma of malignant astrocytoma type with only half the growth rate of the RG2 cells (2). The N32 tumor implanted in rats was treated with intracranial electrochemotherapy and enhanced uptake of [111In]bleomycin from intracranial ECT was also demonstrated with... (More)

The first attempt to apply electrochemotherapy (ECT) to the brain was reported in 1993 by Salford et al. 1993 (1). They managed to significantly prolong the survival of RG2 glioma bearing Fischer-344 rats by 200% by iv administration of bleomycin followed by intracranial electrochemotherapy with exponential decaying pulses. In collaboration with the department of tumor immunology, Lund University, an ethyl-nitroso-urea induced rat glioma cell line (N32) is developed that produces glioma of malignant astrocytoma type with only half the growth rate of the RG2 cells (2). The N32 tumor implanted in rats was treated with intracranial electrochemotherapy and enhanced uptake of [111In]bleomycin from intracranial ECT was also demonstrated with a scintillation camera (3). (111)In-labeled bleomycin has been used to investigate the uptake and retention after ECT treatment of subcutaneous N32 tumors (4).

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
keywords
Journal Article
in
Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery
editor
Jaroszeski, Mark; Heller, Richard; Gilbert, Richard; ; and
volume
37
pages
7 - 313
publisher
Humana Press
ISBN
978-1-59259-080-3
978-0-89603-606-2
DOI
10.1385/1-59259-080-2:313
language
English
LU publication?
yes
id
927a337f-d6c3-4624-90a0-7b81f4894e97
date added to LUP
2017-04-05 14:29:16
date last changed
2017-04-05 16:39:19
@inbook{927a337f-d6c3-4624-90a0-7b81f4894e97,
  abstract     = {<p>The first attempt to apply electrochemotherapy (ECT) to the brain was reported in 1993 by Salford et al. 1993 (1). They managed to significantly prolong the survival of RG2 glioma bearing Fischer-344 rats by 200% by iv administration of bleomycin followed by intracranial electrochemotherapy with exponential decaying pulses. In collaboration with the department of tumor immunology, Lund University, an ethyl-nitroso-urea induced rat glioma cell line (N32) is developed that produces glioma of malignant astrocytoma type with only half the growth rate of the RG2 cells (2). The N32 tumor implanted in rats was treated with intracranial electrochemotherapy and enhanced uptake of [111In]bleomycin from intracranial ECT was also demonstrated with a scintillation camera (3). (111)In-labeled bleomycin has been used to investigate the uptake and retention after ECT treatment of subcutaneous N32 tumors (4).</p>},
  author       = {Salford, L G and Engström, P and Persson, B R},
  editor       = {Jaroszeski, Mark and Heller, Richard and Gilbert, Richard},
  isbn         = {978-1-59259-080-3},
  keyword      = {Journal Article},
  language     = {eng},
  pages        = {7--313},
  publisher    = {Humana Press},
  series       = {Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery},
  title        = {Treatment of rat glioma with electrochemotherapy},
  url          = {http://dx.doi.org/10.1385/1-59259-080-2:313},
  volume       = {37},
  year         = {2000},
}