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Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery

Reinstrup, Peter LU ; Ståhl, Nils LU ; Mellergård, Pekka LU ; Uski, Tore LU ; Ungerstedt, Urban and Nordström, Carl-Henrik LU (2000) In Neurosurgery 47(3). p.701-710
Abstract
OBJECTIVE: The study was undertaken to measure baseline values for chemical markers in human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral microdialysis. METHODS: Microdialysis catheters were inserted into normal posterior frontal cerebral cortex in nine patients who were undergoing surgery to treat benign lesions of the posterior fossa. The perfusion rate was 1.0 microl/min during anesthesia/neurosurgery and the early postoperative course and 0.3 microl/min during the later course. Bedside biochemical analyses of glucose, pyruvate, lactate, glycerol, glutamate, and urea were performed before, during, and after neurosurgery. After the bedside analyses, all samples were frozen for subsequent high-performance... (More)
OBJECTIVE: The study was undertaken to measure baseline values for chemical markers in human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral microdialysis. METHODS: Microdialysis catheters were inserted into normal posterior frontal cerebral cortex in nine patients who were undergoing surgery to treat benign lesions of the posterior fossa. The perfusion rate was 1.0 microl/min during anesthesia/neurosurgery and the early postoperative course and 0.3 microl/min during the later course. Bedside biochemical analyses of glucose, pyruvate, lactate, glycerol, glutamate, and urea were performed before, during, and after neurosurgery. After the bedside analyses, all samples were frozen for subsequent high-performance liquid chromatographic analyses of amino acids. RESULTS: The following baseline values were obtained during wakefulness (perfusion rate, 0.3 microl/min): glucose, 1.7+/-0.9 mmol/L; lactate, 2.9+/-0.9 mmol/L; pyruvate, 166+/-47 micromol/L; lactate/pyruvate ratio, 23+/-4; glycerol, 82+/-44 micromol/L; glutamate, 16+/-16 mmol/L; urea, 4.4+/-1.7 mmol/L. Marked increases in the levels of all chemical markers were observed at the beginning and end of anesthesia/surgery. CONCLUSION: The study provides human baseline levels for biochemical markers that can presently be measured at the bedside during neurointensive care. In addition, some changes that occurred under varying physiological conditions are described. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurosurgery
volume
47
issue
3
pages
701 - 710
publisher
Oxford University Press
external identifiers
  • pmid:10981758
  • scopus:0034521193
ISSN
0148-396X
language
English
LU publication?
yes
id
92d344c0-4e43-4761-80a5-9e81fa7a0808 (old id 1117410)
alternative location
http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200009000-00035.htm;jsessionid=LykWrkJns8kTJwWscpr69r1dXVn7sJLbTHpShkhdNLQLg2LbmZWd!1979722158!181195629!8091!-1
date added to LUP
2016-04-01 17:13:40
date last changed
2022-03-15 06:04:23
@article{92d344c0-4e43-4761-80a5-9e81fa7a0808,
  abstract     = {{OBJECTIVE: The study was undertaken to measure baseline values for chemical markers in human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral microdialysis. METHODS: Microdialysis catheters were inserted into normal posterior frontal cerebral cortex in nine patients who were undergoing surgery to treat benign lesions of the posterior fossa. The perfusion rate was 1.0 microl/min during anesthesia/neurosurgery and the early postoperative course and 0.3 microl/min during the later course. Bedside biochemical analyses of glucose, pyruvate, lactate, glycerol, glutamate, and urea were performed before, during, and after neurosurgery. After the bedside analyses, all samples were frozen for subsequent high-performance liquid chromatographic analyses of amino acids. RESULTS: The following baseline values were obtained during wakefulness (perfusion rate, 0.3 microl/min): glucose, 1.7+/-0.9 mmol/L; lactate, 2.9+/-0.9 mmol/L; pyruvate, 166+/-47 micromol/L; lactate/pyruvate ratio, 23+/-4; glycerol, 82+/-44 micromol/L; glutamate, 16+/-16 mmol/L; urea, 4.4+/-1.7 mmol/L. Marked increases in the levels of all chemical markers were observed at the beginning and end of anesthesia/surgery. CONCLUSION: The study provides human baseline levels for biochemical markers that can presently be measured at the bedside during neurointensive care. In addition, some changes that occurred under varying physiological conditions are described.}},
  author       = {{Reinstrup, Peter and Ståhl, Nils and Mellergård, Pekka and Uski, Tore and Ungerstedt, Urban and Nordström, Carl-Henrik}},
  issn         = {{0148-396X}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{701--710}},
  publisher    = {{Oxford University Press}},
  series       = {{Neurosurgery}},
  title        = {{Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery}},
  url          = {{http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200009000-00035.htm;jsessionid=LykWrkJns8kTJwWscpr69r1dXVn7sJLbTHpShkhdNLQLg2LbmZWd!1979722158!181195629!8091!-1}},
  volume       = {{47}},
  year         = {{2000}},
}