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Characterization of Streptococcus pneumoniae detected in clinical respiratory tract samples in southern Sweden 2 to 4 years after introduction of PCV13

Uddén, Fabian LU orcid ; Rünow, Elisabeth LU orcid ; Slotved, Hans Christian ; Fuursted, Kurt ; Ahl, Jonas LU and Riesbeck, Kristian LU orcid (2021) In Journal of Infection 83(2). p.190-196
Abstract

Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and... (More)

Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and 19A (5%). The most common nonvaccine serotypes were 11A (10%), 23B (10%), 15A (6%) and 35F (5%). Isolates exhibiting serotype 15A or 23B were often multidrug-resistant (21%) or penicillin nonsusceptible (38%), respectively. Conclusions: The overall proportion of serotype 19A was halved compared to a previous observation period when PCV10 was used (years 2011–2013), suggesting herd protection related to PCV13. The proportion of serotype 3 was, however, unchanged. Despite most nonvaccine serotypes causing mucosal infections have a low invasive potential, certain antibiotic resistant serotypes may pose a clinical problem.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antimicrobial resistance, Epidemiology, Respiratory tract infection, Serotype, Streptococcus pneumoniae
in
Journal of Infection
volume
83
issue
2
pages
190 - 196
publisher
W.B. Saunders
external identifiers
  • pmid:34062179
  • scopus:85107883113
ISSN
0163-4453
DOI
10.1016/j.jinf.2021.05.031
language
English
LU publication?
yes
id
92e73a8b-f1a7-43b6-8c60-793e798da64d
date added to LUP
2021-07-15 14:20:48
date last changed
2024-06-15 13:31:31
@article{92e73a8b-f1a7-43b6-8c60-793e798da64d,
  abstract     = {{<p>Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and 19A (5%). The most common nonvaccine serotypes were 11A (10%), 23B (10%), 15A (6%) and 35F (5%). Isolates exhibiting serotype 15A or 23B were often multidrug-resistant (21%) or penicillin nonsusceptible (38%), respectively. Conclusions: The overall proportion of serotype 19A was halved compared to a previous observation period when PCV10 was used (years 2011–2013), suggesting herd protection related to PCV13. The proportion of serotype 3 was, however, unchanged. Despite most nonvaccine serotypes causing mucosal infections have a low invasive potential, certain antibiotic resistant serotypes may pose a clinical problem.</p>}},
  author       = {{Uddén, Fabian and Rünow, Elisabeth and Slotved, Hans Christian and Fuursted, Kurt and Ahl, Jonas and Riesbeck, Kristian}},
  issn         = {{0163-4453}},
  keywords     = {{Antimicrobial resistance; Epidemiology; Respiratory tract infection; Serotype; Streptococcus pneumoniae}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{190--196}},
  publisher    = {{W.B. Saunders}},
  series       = {{Journal of Infection}},
  title        = {{Characterization of Streptococcus pneumoniae detected in clinical respiratory tract samples in southern Sweden 2 to 4 years after introduction of PCV13}},
  url          = {{http://dx.doi.org/10.1016/j.jinf.2021.05.031}},
  doi          = {{10.1016/j.jinf.2021.05.031}},
  volume       = {{83}},
  year         = {{2021}},
}