Characterization of Streptococcus pneumoniae detected in clinical respiratory tract samples in southern Sweden 2 to 4 years after introduction of PCV13
(2021) In Journal of Infection 83(2). p.190-196- Abstract
Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and... (More)
Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and 19A (5%). The most common nonvaccine serotypes were 11A (10%), 23B (10%), 15A (6%) and 35F (5%). Isolates exhibiting serotype 15A or 23B were often multidrug-resistant (21%) or penicillin nonsusceptible (38%), respectively. Conclusions: The overall proportion of serotype 19A was halved compared to a previous observation period when PCV10 was used (years 2011–2013), suggesting herd protection related to PCV13. The proportion of serotype 3 was, however, unchanged. Despite most nonvaccine serotypes causing mucosal infections have a low invasive potential, certain antibiotic resistant serotypes may pose a clinical problem.
(Less)
- author
- Uddén, Fabian LU ; Rünow, Elisabeth LU ; Slotved, Hans Christian ; Fuursted, Kurt ; Ahl, Jonas LU and Riesbeck, Kristian LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antimicrobial resistance, Epidemiology, Respiratory tract infection, Serotype, Streptococcus pneumoniae
- in
- Journal of Infection
- volume
- 83
- issue
- 2
- pages
- 190 - 196
- publisher
- W.B. Saunders
- external identifiers
-
- pmid:34062179
- scopus:85107883113
- ISSN
- 0163-4453
- DOI
- 10.1016/j.jinf.2021.05.031
- language
- English
- LU publication?
- yes
- id
- 92e73a8b-f1a7-43b6-8c60-793e798da64d
- date added to LUP
- 2021-07-15 14:20:48
- date last changed
- 2024-09-21 22:33:10
@article{92e73a8b-f1a7-43b6-8c60-793e798da64d, abstract = {{<p>Objective: To determine the serotype distribution and antimicrobial resistance of Streptococcus pneumoniae associated with mucosal infections in patients of all ages, 2 to 4 years after the transition from a 10-valent pneumococcal conjugate vaccine (PCV10) to PCV13 in the childhood immunization programme. Methods: Background information and antimicrobial susceptibility data regarding all respiratory tract, middle ear, and conjunctival samples positive for growth of S. pneumoniae (n = 2,131) were collected during 18 months in 2016–2018. Available corresponding bacterial isolates were serotyped by PCR and/or antisera (n = 1,858). Results: In total, 17% of isolates were covered by PCV13, predominantly represented by serotypes 3 (9%) and 19A (5%). The most common nonvaccine serotypes were 11A (10%), 23B (10%), 15A (6%) and 35F (5%). Isolates exhibiting serotype 15A or 23B were often multidrug-resistant (21%) or penicillin nonsusceptible (38%), respectively. Conclusions: The overall proportion of serotype 19A was halved compared to a previous observation period when PCV10 was used (years 2011–2013), suggesting herd protection related to PCV13. The proportion of serotype 3 was, however, unchanged. Despite most nonvaccine serotypes causing mucosal infections have a low invasive potential, certain antibiotic resistant serotypes may pose a clinical problem.</p>}}, author = {{Uddén, Fabian and Rünow, Elisabeth and Slotved, Hans Christian and Fuursted, Kurt and Ahl, Jonas and Riesbeck, Kristian}}, issn = {{0163-4453}}, keywords = {{Antimicrobial resistance; Epidemiology; Respiratory tract infection; Serotype; Streptococcus pneumoniae}}, language = {{eng}}, number = {{2}}, pages = {{190--196}}, publisher = {{W.B. Saunders}}, series = {{Journal of Infection}}, title = {{Characterization of Streptococcus pneumoniae detected in clinical respiratory tract samples in southern Sweden 2 to 4 years after introduction of PCV13}}, url = {{http://dx.doi.org/10.1016/j.jinf.2021.05.031}}, doi = {{10.1016/j.jinf.2021.05.031}}, volume = {{83}}, year = {{2021}}, }