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International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Lindgren, Arne G. LU ; Braun, Robynne G. ; Juhl Majersik, Jennifer ; Clatworthy, Philip ; Mainali, Shraddha ; Derdeyn, Colin P. ; Maguire, Jane ; Jern, Christina ; Rosand, Jonathan and Cole, John W , et al. (2022) In International Journal of Stroke 17(3). p.260-268
Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus... (More)

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Data collection, genetics, ischemic stroke, outcome, phenotype, recovery, standardization
in
International Journal of Stroke
volume
17
issue
3
pages
9 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85105386996
  • pmid:33739214
ISSN
1747-4930
DOI
10.1177/17474930211007288
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 World Stroke Organization.
id
92f0cebd-e87d-4658-9958-bc5c9be5a131
date added to LUP
2022-12-29 14:22:36
date last changed
2024-06-14 00:57:47
@article{92f0cebd-e87d-4658-9958-bc5c9be5a131,
  abstract     = {{<p>Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.</p>}},
  author       = {{Lindgren, Arne G. and Braun, Robynne G. and Juhl Majersik, Jennifer and Clatworthy, Philip and Mainali, Shraddha and Derdeyn, Colin P. and Maguire, Jane and Jern, Christina and Rosand, Jonathan and Cole, John W and Lee, Jin Moo and Khatri, Pooja and Nyquist, Paul and Debette, Stéphanie and Keat Wei, Loo and Rundek, Tatjana and Leifer, Dana and Thijs, Vincent and Lemmens, Robin and Heitsch, Laura and Prasad, Kameshwar and Jimenez Conde, Jordi and Dichgans, Martin and Rost, Natalia S. and Cramer, Steven C. and Bernhardt, Julie and Worrall, Bradford B. and Fernandez-Cadenas, Israel}},
  issn         = {{1747-4930}},
  keywords     = {{Data collection; genetics; ischemic stroke; outcome; phenotype; recovery; standardization}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{260--268}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Journal of Stroke}},
  title        = {{International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery}},
  url          = {{http://dx.doi.org/10.1177/17474930211007288}},
  doi          = {{10.1177/17474930211007288}},
  volume       = {{17}},
  year         = {{2022}},
}