International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
(2022) In International Journal of Stroke 17(3). p.260-268- Abstract
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus... (More)
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2022-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Data collection, genetics, ischemic stroke, outcome, phenotype, recovery, standardization
- in
- International Journal of Stroke
- volume
- 17
- issue
- 3
- pages
- 9 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85105386996
- pmid:33739214
- ISSN
- 1747-4930
- DOI
- 10.1177/17474930211007288
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 World Stroke Organization.
- id
- 92f0cebd-e87d-4658-9958-bc5c9be5a131
- date added to LUP
- 2022-12-29 14:22:36
- date last changed
- 2024-09-20 10:11:07
@article{92f0cebd-e87d-4658-9958-bc5c9be5a131, abstract = {{<p>Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.</p>}}, author = {{Lindgren, Arne G. and Braun, Robynne G. and Juhl Majersik, Jennifer and Clatworthy, Philip and Mainali, Shraddha and Derdeyn, Colin P. and Maguire, Jane and Jern, Christina and Rosand, Jonathan and Cole, John W and Lee, Jin Moo and Khatri, Pooja and Nyquist, Paul and Debette, Stéphanie and Keat Wei, Loo and Rundek, Tatjana and Leifer, Dana and Thijs, Vincent and Lemmens, Robin and Heitsch, Laura and Prasad, Kameshwar and Jimenez Conde, Jordi and Dichgans, Martin and Rost, Natalia S. and Cramer, Steven C. and Bernhardt, Julie and Worrall, Bradford B. and Fernandez-Cadenas, Israel}}, issn = {{1747-4930}}, keywords = {{Data collection; genetics; ischemic stroke; outcome; phenotype; recovery; standardization}}, language = {{eng}}, number = {{3}}, pages = {{260--268}}, publisher = {{Wiley-Blackwell}}, series = {{International Journal of Stroke}}, title = {{International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery}}, url = {{http://dx.doi.org/10.1177/17474930211007288}}, doi = {{10.1177/17474930211007288}}, volume = {{17}}, year = {{2022}}, }