Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Relationships Between Diabetes Duration, Metabolic Control and β‐cell Function in a Representative Population of Type 2 Diabetic Patients in Sweden

Clauson, P. ; Linnarsson, R. ; Gottsäter, A. LU ; Sundkvist, G. LU and Grill, V. (1994) In Diabetic Medicine 11(8). p.794-801
Abstract

To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m−2), however 76/210 (36%), had normal weight (BMI < 25 kg m−2). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l−1 in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l−1 in... (More)

To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m−2), however 76/210 (36%), had normal weight (BMI < 25 kg m−2). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l−1 in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l−1 in those with 5–10 years of duration, p < 0.01 and HbA1c from 6.4 ± 0.2 to 7.4 ± 0.4%, p < 0.05. Fasting C‐peptide levels decreased after 10 years duration from 0.90 ± 0.06 nmol l−1 during 5–10 to 0.69 ± 0.08 nmol l−1 during 10–15 years of diabetes, p < 0.05. The proportion of insulin treated patients increased from 13% (12/94) with 0–5 years of duration to 33% (13/39) with 10–15 years and 60% (18/30) with more than 15 years of duration. In conclusion in Type 2 diabetic patients without signs of autoimmunity, metabolic control, and β‐cell function deteriorate with increasing duration of diabetes, leading to common but not inevitable occurrence of ‘secondary failure’. 1994 Diabetes UK

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C‐peptide, Secondary failure, Sulphonylurea Pancreatic, Type 2 diabetes mellitus, β‐cell Islet cell antibodies
in
Diabetic Medicine
volume
11
issue
8
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:7851075
  • scopus:0028135578
ISSN
0742-3071
DOI
10.1111/j.1464-5491.1994.tb00355.x
language
English
LU publication?
no
id
9300c765-70ee-4258-acc5-529d00530f74
date added to LUP
2020-12-11 14:33:24
date last changed
2024-01-03 00:49:43
@article{9300c765-70ee-4258-acc5-529d00530f74,
  abstract     = {{<p>To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset &gt; 35 years, fasting levels of C‐peptide &gt; 0.04 nmol l<sup>−1</sup>, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m<sup>−2</sup>), however 76/210 (36%), had normal weight (BMI &lt; 25 kg m<sup>−2</sup>). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l<sup>−1</sup> in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l<sup>−1</sup> in those with 5–10 years of duration, p &lt; 0.01 and HbA<sub>1c</sub> from 6.4 ± 0.2 to 7.4 ± 0.4%, p &lt; 0.05. Fasting C‐peptide levels decreased after 10 years duration from 0.90 ± 0.06 nmol l<sup>−1</sup> during 5–10 to 0.69 ± 0.08 nmol l<sup>−1</sup> during 10–15 years of diabetes, p &lt; 0.05. The proportion of insulin treated patients increased from 13% (12/94) with 0–5 years of duration to 33% (13/39) with 10–15 years and 60% (18/30) with more than 15 years of duration. In conclusion in Type 2 diabetic patients without signs of autoimmunity, metabolic control, and β‐cell function deteriorate with increasing duration of diabetes, leading to common but not inevitable occurrence of ‘secondary failure’. 1994 Diabetes UK</p>}},
  author       = {{Clauson, P. and Linnarsson, R. and Gottsäter, A. and Sundkvist, G. and Grill, V.}},
  issn         = {{0742-3071}},
  keywords     = {{C‐peptide; Secondary failure; Sulphonylurea Pancreatic; Type 2 diabetes mellitus; β‐cell Islet cell antibodies}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{794--801}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Diabetic Medicine}},
  title        = {{Relationships Between Diabetes Duration, Metabolic Control and β‐cell Function in a Representative Population of Type 2 Diabetic Patients in Sweden}},
  url          = {{http://dx.doi.org/10.1111/j.1464-5491.1994.tb00355.x}},
  doi          = {{10.1111/j.1464-5491.1994.tb00355.x}},
  volume       = {{11}},
  year         = {{1994}},
}