Relationships Between Diabetes Duration, Metabolic Control and β‐cell Function in a Representative Population of Type 2 Diabetic Patients in Sweden
(1994) In Diabetic Medicine 11(8). p.794-801- Abstract
To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m−2), however 76/210 (36%), had normal weight (BMI < 25 kg m−2). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l−1 in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l−1 in... (More)
To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l−1, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m−2), however 76/210 (36%), had normal weight (BMI < 25 kg m−2). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l−1 in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l−1 in those with 5–10 years of duration, p < 0.01 and HbA1c from 6.4 ± 0.2 to 7.4 ± 0.4%, p < 0.05. Fasting C‐peptide levels decreased after 10 years duration from 0.90 ± 0.06 nmol l−1 during 5–10 to 0.69 ± 0.08 nmol l−1 during 10–15 years of diabetes, p < 0.05. The proportion of insulin treated patients increased from 13% (12/94) with 0–5 years of duration to 33% (13/39) with 10–15 years and 60% (18/30) with more than 15 years of duration. In conclusion in Type 2 diabetic patients without signs of autoimmunity, metabolic control, and β‐cell function deteriorate with increasing duration of diabetes, leading to common but not inevitable occurrence of ‘secondary failure’. 1994 Diabetes UK
(Less)
- author
- Clauson, P. ; Linnarsson, R. ; Gottsäter, A. LU ; Sundkvist, G. LU and Grill, V.
- publishing date
- 1994-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C‐peptide, Secondary failure, Sulphonylurea Pancreatic, Type 2 diabetes mellitus, β‐cell Islet cell antibodies
- in
- Diabetic Medicine
- volume
- 11
- issue
- 8
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0028135578
- pmid:7851075
- ISSN
- 0742-3071
- DOI
- 10.1111/j.1464-5491.1994.tb00355.x
- language
- English
- LU publication?
- no
- id
- 9300c765-70ee-4258-acc5-529d00530f74
- date added to LUP
- 2020-12-11 14:33:24
- date last changed
- 2024-08-23 09:41:03
@article{9300c765-70ee-4258-acc5-529d00530f74, abstract = {{<p>To clarify whether metabolic control and β‐cell function deteriorate with increasing duration of diabetes, we investigated in a cross‐sectional study Type 2 diabetic patients in an area‐based population. Type 2 diabetic patients (n = 231: 112 males, 119 females) were identified by age at onset > 35 years, fasting levels of C‐peptide > 0.04 nmol l<sup>−1</sup>, and absence of islet cell antibodies. Body weight was slightly elevated (BMI 26.8 ± 0.3 kg m<sup>−2</sup>), however 76/210 (36%), had normal weight (BMI < 25 kg m<sup>−2</sup>). Fasting blood glucose rose significantly during the first 10 years of known diabetes from 8.2 ± 0.3 mmol l<sup>−1</sup> in patients with 0–5 years of duration to 9.9 ± 0.7 mmol l<sup>−1</sup> in those with 5–10 years of duration, p < 0.01 and HbA<sub>1c</sub> from 6.4 ± 0.2 to 7.4 ± 0.4%, p < 0.05. Fasting C‐peptide levels decreased after 10 years duration from 0.90 ± 0.06 nmol l<sup>−1</sup> during 5–10 to 0.69 ± 0.08 nmol l<sup>−1</sup> during 10–15 years of diabetes, p < 0.05. The proportion of insulin treated patients increased from 13% (12/94) with 0–5 years of duration to 33% (13/39) with 10–15 years and 60% (18/30) with more than 15 years of duration. In conclusion in Type 2 diabetic patients without signs of autoimmunity, metabolic control, and β‐cell function deteriorate with increasing duration of diabetes, leading to common but not inevitable occurrence of ‘secondary failure’. 1994 Diabetes UK</p>}}, author = {{Clauson, P. and Linnarsson, R. and Gottsäter, A. and Sundkvist, G. and Grill, V.}}, issn = {{0742-3071}}, keywords = {{C‐peptide; Secondary failure; Sulphonylurea Pancreatic; Type 2 diabetes mellitus; β‐cell Islet cell antibodies}}, language = {{eng}}, number = {{8}}, pages = {{794--801}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetic Medicine}}, title = {{Relationships Between Diabetes Duration, Metabolic Control and β‐cell Function in a Representative Population of Type 2 Diabetic Patients in Sweden}}, url = {{http://dx.doi.org/10.1111/j.1464-5491.1994.tb00355.x}}, doi = {{10.1111/j.1464-5491.1994.tb00355.x}}, volume = {{11}}, year = {{1994}}, }