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Gene Expression Regulation in Airway Pathogens : Importance for Otitis Media

Janoušková, Martina LU ; Straw, Megan Laura LU ; Su, Yu Ching LU and Riesbeck, Kristian LU orcid (2022) In Frontiers in cellular and infection microbiology 12.
Abstract

Otitis media (OM) is an inflammatory disorder in the middle ear. It is mainly caused by viruses or bacteria associated with the airways. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the three main pathogens in infection-related OM, especially in younger children. In this review, we will focus upon the multifaceted gene regulation mechanisms that are well-orchestrated in S. pneumoniae, H. influenzae, and M. catarrhalis during the course of infection in the middle ear either in experimental OM or in clinical settings. The sophisticated findings from the past 10 years on how the othopathogens govern their virulence phenotypes for survival and host adaptation via phase variation- and quorum... (More)

Otitis media (OM) is an inflammatory disorder in the middle ear. It is mainly caused by viruses or bacteria associated with the airways. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the three main pathogens in infection-related OM, especially in younger children. In this review, we will focus upon the multifaceted gene regulation mechanisms that are well-orchestrated in S. pneumoniae, H. influenzae, and M. catarrhalis during the course of infection in the middle ear either in experimental OM or in clinical settings. The sophisticated findings from the past 10 years on how the othopathogens govern their virulence phenotypes for survival and host adaptation via phase variation- and quorum sensing-dependent gene regulation, will be systematically discussed. Comprehensive understanding of gene expression regulation mechanisms employed by pathogens during the onset of OM may provide new insights for the design of a new generation of antimicrobial agents in the fight against bacterial pathogens while combating the serious emergence of antimicrobial resistance.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene expression regulation, Haemophilus influenzae, Moraxella catarrhalis, otitis media, Streptococcus pneumoniae
in
Frontiers in cellular and infection microbiology
volume
12
article number
826018
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85125811669
  • pmid:35252035
ISSN
2235-2988
DOI
10.3389/fcimb.2022.826018
language
English
LU publication?
yes
id
931988a0-3f4b-438a-a271-6e07e28ff064
date added to LUP
2022-04-14 11:20:30
date last changed
2024-06-20 01:49:49
@article{931988a0-3f4b-438a-a271-6e07e28ff064,
  abstract     = {{<p>Otitis media (OM) is an inflammatory disorder in the middle ear. It is mainly caused by viruses or bacteria associated with the airways. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the three main pathogens in infection-related OM, especially in younger children. In this review, we will focus upon the multifaceted gene regulation mechanisms that are well-orchestrated in S. pneumoniae, H. influenzae, and M. catarrhalis during the course of infection in the middle ear either in experimental OM or in clinical settings. The sophisticated findings from the past 10 years on how the othopathogens govern their virulence phenotypes for survival and host adaptation via phase variation- and quorum sensing-dependent gene regulation, will be systematically discussed. Comprehensive understanding of gene expression regulation mechanisms employed by pathogens during the onset of OM may provide new insights for the design of a new generation of antimicrobial agents in the fight against bacterial pathogens while combating the serious emergence of antimicrobial resistance.</p>}},
  author       = {{Janoušková, Martina and Straw, Megan Laura and Su, Yu Ching and Riesbeck, Kristian}},
  issn         = {{2235-2988}},
  keywords     = {{gene expression regulation; Haemophilus influenzae; Moraxella catarrhalis; otitis media; Streptococcus pneumoniae}},
  language     = {{eng}},
  month        = {{02}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in cellular and infection microbiology}},
  title        = {{Gene Expression Regulation in Airway Pathogens : Importance for Otitis Media}},
  url          = {{http://dx.doi.org/10.3389/fcimb.2022.826018}},
  doi          = {{10.3389/fcimb.2022.826018}},
  volume       = {{12}},
  year         = {{2022}},
}