Islet cell antibody reactivity with human fetal pancreatic islets
(1991) In Diabetes Research and Clinical Practice 14(1). p.1-7- Abstract
To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/934c6871-7708-40a5-93f4-f7435f4026f5
- author
- Sundkvist, Göran LU ; Bergqvist, Agneta ; Weibull, Henrik ; Bergqvist, David ; Fält, Kaj ; Olsson, Mona Landin LU and Lernmark, Åke LU
- organization
- publishing date
- 1991-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autoimmunity, Fetal islets, Islet cell antibodies, Islet cell antigens
- in
- Diabetes Research and Clinical Practice
- volume
- 14
- issue
- 1
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0025938112
- pmid:1748059
- ISSN
- 0168-8227
- DOI
- 10.1016/0168-8227(91)90046-G
- language
- English
- LU publication?
- yes
- id
- 934c6871-7708-40a5-93f4-f7435f4026f5
- date added to LUP
- 2019-09-11 09:38:16
- date last changed
- 2024-03-13 08:24:52
@article{934c6871-7708-40a5-93f4-f7435f4026f5, abstract = {{<p>To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.</p>}}, author = {{Sundkvist, Göran and Bergqvist, Agneta and Weibull, Henrik and Bergqvist, David and Fält, Kaj and Olsson, Mona Landin and Lernmark, Åke}}, issn = {{0168-8227}}, keywords = {{Autoimmunity; Fetal islets; Islet cell antibodies; Islet cell antigens}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{1--7}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Islet cell antibody reactivity with human fetal pancreatic islets}}, url = {{http://dx.doi.org/10.1016/0168-8227(91)90046-G}}, doi = {{10.1016/0168-8227(91)90046-G}}, volume = {{14}}, year = {{1991}}, }