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Islet cell antibody reactivity with human fetal pancreatic islets

Sundkvist, Göran LU ; Bergqvist, Agneta ; Weibull, Henrik ; Bergqvist, David ; Fält, Kaj ; Olsson, Mona Landin LU and Lernmark, Åke LU orcid (1991) In Diabetes Research and Clinical Practice 14(1). p.1-7
Abstract

To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Fetal islets, Islet cell antibodies, Islet cell antigens
in
Diabetes Research and Clinical Practice
volume
14
issue
1
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:0025938112
  • pmid:1748059
ISSN
0168-8227
DOI
10.1016/0168-8227(91)90046-G
language
English
LU publication?
yes
id
934c6871-7708-40a5-93f4-f7435f4026f5
date added to LUP
2019-09-11 09:38:16
date last changed
2024-03-13 08:24:52
@article{934c6871-7708-40a5-93f4-f7435f4026f5,
  abstract     = {{<p>To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.</p>}},
  author       = {{Sundkvist, Göran and Bergqvist, Agneta and Weibull, Henrik and Bergqvist, David and Fält, Kaj and Olsson, Mona Landin and Lernmark, Åke}},
  issn         = {{0168-8227}},
  keywords     = {{Autoimmunity; Fetal islets; Islet cell antibodies; Islet cell antigens}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{1--7}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Islet cell antibody reactivity with human fetal pancreatic islets}},
  url          = {{http://dx.doi.org/10.1016/0168-8227(91)90046-G}},
  doi          = {{10.1016/0168-8227(91)90046-G}},
  volume       = {{14}},
  year         = {{1991}},
}