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“Oxygen tone” drives stage-specific OPC phenotypes for cell-based stroke therapy

Kokaia, Zaal LU orcid and Palma-Tortosa, Sara LU (2025) In Stem Cell Reports 20(11).
Abstract

Oligodendrocyte precursor cells (OPCs) display functional plasticity beyond myelination. Kuwata et al. explore how hypoxia shapes OPC features after ischemic stroke. Combining single-cell transcriptomics with in vivo and ex vivo models, they reveal oxygen-dependent OPC phenotypes promoting angiogenesis and remyelination, highlighting OPC versatility and potential for novel stroke cell therapies.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem Cell Reports
volume
20
issue
11
article number
102709
publisher
Cell Press
external identifiers
  • pmid:41223837
  • scopus:105021700536
ISSN
2213-6711
DOI
10.1016/j.stemcr.2025.102709
language
English
LU publication?
yes
id
935a5c11-6b53-41e6-ae7d-0327c8d0601f
date added to LUP
2026-02-10 13:59:17
date last changed
2026-06-17 06:40:32
@misc{935a5c11-6b53-41e6-ae7d-0327c8d0601f,
  abstract     = {{<p>Oligodendrocyte precursor cells (OPCs) display functional plasticity beyond myelination. Kuwata et al. explore how hypoxia shapes OPC features after ischemic stroke. Combining single-cell transcriptomics with in vivo and ex vivo models, they reveal oxygen-dependent OPC phenotypes promoting angiogenesis and remyelination, highlighting OPC versatility and potential for novel stroke cell therapies.</p>}},
  author       = {{Kokaia, Zaal and Palma-Tortosa, Sara}},
  issn         = {{2213-6711}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  publisher    = {{Cell Press}},
  series       = {{Stem Cell Reports}},
  title        = {{“Oxygen tone” drives stage-specific OPC phenotypes for cell-based stroke therapy}},
  url          = {{http://dx.doi.org/10.1016/j.stemcr.2025.102709}},
  doi          = {{10.1016/j.stemcr.2025.102709}},
  volume       = {{20}},
  year         = {{2025}},
}