Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments
(2004) In Journal of Controlled Release 97(3). p.453-465- Abstract
- A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the... (More)
- A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the lag times compared well with the experimental data. The distributions were used as input data for the multiple pellet model, in order to predict the release profiles on the dose level, showing results consistent with the measured dose release. The dose-predictive ability of the model was demonstrated in simulations by studying the effect of a change in the size of the single subunits (of constant total dose), showing that smaller pellets give an increased release rate with less variation. The model for predicting dose-release profiles could be of great value in optimising the performance of an existing formulation, as well as in the development of a new control led-release pharmaceutical. (C) 2004 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/138819
- author
- Borgquist, Per LU ; Nevsten, Pernilla LU ; Nilsson, Bernt LU ; Wallenberg, Reine LU and Axelsson, Anders LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Controlled Release
- volume
- 97
- issue
- 3
- pages
- 453 - 465
- publisher
- Elsevier
- external identifiers
-
- pmid:15212877
- wos:000222531500006
- scopus:3042690833
- ISSN
- 1873-4995
- DOI
- 10.1016/j.jconrel.2004.03.024
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Chemical Engineering (011001014), Polymer and Materials Chemistry (LTH) (011001041)
- id
- 9389c008-a34e-434c-b8d7-154647fe7a5b (old id 138819)
- date added to LUP
- 2016-04-01 11:50:54
- date last changed
- 2023-11-11 03:09:46
@article{9389c008-a34e-434c-b8d7-154647fe7a5b,
abstract = {{A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the lag times compared well with the experimental data. The distributions were used as input data for the multiple pellet model, in order to predict the release profiles on the dose level, showing results consistent with the measured dose release. The dose-predictive ability of the model was demonstrated in simulations by studying the effect of a change in the size of the single subunits (of constant total dose), showing that smaller pellets give an increased release rate with less variation. The model for predicting dose-release profiles could be of great value in optimising the performance of an existing formulation, as well as in the development of a new control led-release pharmaceutical. (C) 2004 Elsevier B.V. All rights reserved.}},
author = {{Borgquist, Per and Nevsten, Pernilla and Nilsson, Bernt and Wallenberg, Reine and Axelsson, Anders}},
issn = {{1873-4995}},
language = {{eng}},
number = {{3}},
pages = {{453--465}},
publisher = {{Elsevier}},
series = {{Journal of Controlled Release}},
title = {{Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments}},
url = {{http://dx.doi.org/10.1016/j.jconrel.2004.03.024}},
doi = {{10.1016/j.jconrel.2004.03.024}},
volume = {{97}},
year = {{2004}},
}