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A favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort

Dimovski, Kristian LU ; Orho-Melander, Marju LU and Drake, Isabel LU (2019) In BMC Public Health 19.
Abstract

Background: A healthy lifestyle has been shown to reduce the risk of coronary artery disease (CAD). The extent to which lifestyle influences the risk of CAD for people with pre-existing non-modifiable risk factors is less studied. We therefore examined the associations between a favorable lifestyle and incidence of CAD in population subgroups based on gender, age, educational level, and parental history of myocardial infarction. 

Methods: A total of 26,323 men and women from the Malmö Diet and Cancer study were prospectively followed-up for 18 years. A favorable lifestyle was determined using a four-component lifestyle score based on data collected at baseline: no smoking, no obesity, regular physical activity, and a healthy diet.... (More)

Background: A healthy lifestyle has been shown to reduce the risk of coronary artery disease (CAD). The extent to which lifestyle influences the risk of CAD for people with pre-existing non-modifiable risk factors is less studied. We therefore examined the associations between a favorable lifestyle and incidence of CAD in population subgroups based on gender, age, educational level, and parental history of myocardial infarction. 

Methods: A total of 26,323 men and women from the Malmö Diet and Cancer study were prospectively followed-up for 18 years. A favorable lifestyle was determined using a four-component lifestyle score based on data collected at baseline: no smoking, no obesity, regular physical activity, and a healthy diet. Cox proportional hazards regression models were used to estimate the relative risk of CAD during follow-up and cumulative risk during a 10-year interval. 

Results: A favorable lifestyle was associated with a 44% (95% confidence interval, 38-48%) lower risk of CAD compared to an unfavorable lifestyle. The relative risk was similarly reduced among subjects subdivided by gender, age group, educational level, and parental history of myocardial infarction. These findings corresponded with a reduced standardized 10-year incidence of CAD of around 40% in each subgroup. 

Conclusion: In this population-based cohort, a favorable lifestyle was associated with a significant reduction of CAD across strata of non-modifiable risk factors. These findings provide support for lifestyle modification as a means for risk reduction in a range of subgroups within a general healthy population.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort study, Coronary artery disease, Cumulative risk, Lifestyle, Relative risk
in
BMC Public Health
volume
19
article number
1575
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85075752855
  • pmid:31775698
ISSN
1471-2458
DOI
10.1186/s12889-019-7948-x
language
English
LU publication?
yes
id
93bd60f0-1bf7-450a-99d0-575286652cd5
date added to LUP
2019-12-18 16:15:25
date last changed
2020-09-23 08:02:06
@article{93bd60f0-1bf7-450a-99d0-575286652cd5,
  abstract     = {<p>Background: A healthy lifestyle has been shown to reduce the risk of coronary artery disease (CAD). The extent to which lifestyle influences the risk of CAD for people with pre-existing non-modifiable risk factors is less studied. We therefore examined the associations between a favorable lifestyle and incidence of CAD in population subgroups based on gender, age, educational level, and parental history of myocardial infarction. </p><p>Methods: A total of 26,323 men and women from the Malmö Diet and Cancer study were prospectively followed-up for 18 years. A favorable lifestyle was determined using a four-component lifestyle score based on data collected at baseline: no smoking, no obesity, regular physical activity, and a healthy diet. Cox proportional hazards regression models were used to estimate the relative risk of CAD during follow-up and cumulative risk during a 10-year interval. </p><p>Results: A favorable lifestyle was associated with a 44% (95% confidence interval, 38-48%) lower risk of CAD compared to an unfavorable lifestyle. The relative risk was similarly reduced among subjects subdivided by gender, age group, educational level, and parental history of myocardial infarction. These findings corresponded with a reduced standardized 10-year incidence of CAD of around 40% in each subgroup. </p><p>Conclusion: In this population-based cohort, a favorable lifestyle was associated with a significant reduction of CAD across strata of non-modifiable risk factors. These findings provide support for lifestyle modification as a means for risk reduction in a range of subgroups within a general healthy population.</p>},
  author       = {Dimovski, Kristian and Orho-Melander, Marju and Drake, Isabel},
  issn         = {1471-2458},
  language     = {eng},
  month        = {11},
  publisher    = {BioMed Central (BMC)},
  series       = {BMC Public Health},
  title        = {A favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort},
  url          = {http://dx.doi.org/10.1186/s12889-019-7948-x},
  doi          = {10.1186/s12889-019-7948-x},
  volume       = {19},
  year         = {2019},
}