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Activation of the contact-phase system on bacterial surfaces - A clue to serious comlications in infections deseases

Herwald, Heiko LU orcid ; Mörgelin, Matthias LU ; Olsén, Arne LU ; Rhen, Mikael ; Dahlbäck, Björn LU ; Müller-Esterl, Werner and Björck, Lars LU (1998) In Nature Medicine 4(3). p.298-302
Abstract

Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by... (More)

Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by bacterial surface proteins depletes relevant coagulation factors and causes a hypocoagulatory state. Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
4
issue
3
pages
298 - 302
publisher
Nature Publishing Group
external identifiers
  • pmid:9500602
  • scopus:2642635843
ISSN
1078-8956
DOI
10.1038/nm0398-298
language
English
LU publication?
yes
id
9419ec0c-939d-4380-a52b-cda2ef1d3ffe
date added to LUP
2019-12-10 20:25:32
date last changed
2025-11-14 19:05:18
@article{9419ec0c-939d-4380-a52b-cda2ef1d3ffe,
  abstract     = {{<p>Fever, hypotension and bleeding disorders are common symptoms of sepsis and septic shock. The activation of the contact-phase system is thought to contribute to the development of these severe disease states by triggering proinflammatory and procoagulatory cascades; however, the underlying molecular mechanisms are obscure. Here we report that the components of the contact-phase system are assembled on the surface of Escherichia coil and Salmonella through their specific interactions with fibrous bacterial surface proteins, curli and fimbriae. As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension. Absorption of contact-phase proteins and fibrinogen by bacterial surface proteins depletes relevant coagulation factors and causes a hypocoagulatory state. Thus, the complex interplay of microbe surface proteins and host contact-phase factors may contribute to the symptoms of sepsis and septic shock.</p>}},
  author       = {{Herwald, Heiko and Mörgelin, Matthias and Olsén, Arne and Rhen, Mikael and Dahlbäck, Björn and Müller-Esterl, Werner and Björck, Lars}},
  issn         = {{1078-8956}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{298--302}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Medicine}},
  title        = {{Activation of the contact-phase system on bacterial surfaces - A clue to serious comlications in infections deseases}},
  url          = {{http://dx.doi.org/10.1038/nm0398-298}},
  doi          = {{10.1038/nm0398-298}},
  volume       = {{4}},
  year         = {{1998}},
}