Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death : A Swedish national study
(2023) In Psychological Medicine 53(4). p.1639-1648- Abstract
Background How does genetic liability to suicide attempt (SA), suicide death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD), and drug use disorder (DUD) impact on risk for SA and SD? Methods In the Swedish general population born 1932-1995 and followed through 2017 (n = 7 661 519), we calculate family genetic risk scores (FGRS) for SA, SD, MD, BD, SZ, AUD, and DUD. Registration for SA and SD was assessed from Swedish national registers. Results In univariate and multivariate models predicting SA, FGRS were highest for SA, AUD, DUD, and MD. In univariate models predicting SD, the strongest FGRS were AUD, DUD, SA, and SD. In multivariate models, the FGRS for SA and AUD were higher in... (More)
Background How does genetic liability to suicide attempt (SA), suicide death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD), and drug use disorder (DUD) impact on risk for SA and SD? Methods In the Swedish general population born 1932-1995 and followed through 2017 (n = 7 661 519), we calculate family genetic risk scores (FGRS) for SA, SD, MD, BD, SZ, AUD, and DUD. Registration for SA and SD was assessed from Swedish national registers. Results In univariate and multivariate models predicting SA, FGRS were highest for SA, AUD, DUD, and MD. In univariate models predicting SD, the strongest FGRS were AUD, DUD, SA, and SD. In multivariate models, the FGRS for SA and AUD were higher in predicting SA while the FGRS for SD, BD, and SZ were higher in predicting SD. Higher FGRS for all disorders significantly predicted both younger age at first SA and frequency of attempts. For SD, higher FGRS for MD, AUD, and SD predicted later age at SD. Mediation of FGRS effects on SA and SD was more pronounced for SD than SA, strongest for AUD, DUD, and SZ FGRS and weakest for MD. Conclusions FGRS for both SA and SD and for our five psychiatric disorders impact on risk for SA and SD in a complex manner. While some of the impact of genetic risk factors for psychiatric disorders on risk for SA and SD is mediated through developing the disorders, these risks also predispose directly to suicidal behaviors.
(Less)
- author
- Kendler, Kenneth S. ; Ohlsson, Henrik LU ; Mościcki, Eve K. ; Sundquist, Jan LU ; Edwards, Alexis C. LU and Sundquist, Kristina LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Genetics, Psychiatric and Substance Use Disorders, Suicide attempt, Suicide Death
- in
- Psychological Medicine
- volume
- 53
- issue
- 4
- pages
- 1639 - 1648
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:85114307222
- pmid:37010214
- ISSN
- 0033-2917
- DOI
- 10.1017/S0033291721003354
- language
- English
- LU publication?
- yes
- id
- 944e85c6-3e69-4ea8-9e28-ec206d7b0f8c
- date added to LUP
- 2021-10-07 11:56:29
- date last changed
- 2024-04-26 03:00:15
@article{944e85c6-3e69-4ea8-9e28-ec206d7b0f8c, abstract = {{<p>Background How does genetic liability to suicide attempt (SA), suicide death (SD), major depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD), and drug use disorder (DUD) impact on risk for SA and SD? Methods In the Swedish general population born 1932-1995 and followed through 2017 (n = 7 661 519), we calculate family genetic risk scores (FGRS) for SA, SD, MD, BD, SZ, AUD, and DUD. Registration for SA and SD was assessed from Swedish national registers. Results In univariate and multivariate models predicting SA, FGRS were highest for SA, AUD, DUD, and MD. In univariate models predicting SD, the strongest FGRS were AUD, DUD, SA, and SD. In multivariate models, the FGRS for SA and AUD were higher in predicting SA while the FGRS for SD, BD, and SZ were higher in predicting SD. Higher FGRS for all disorders significantly predicted both younger age at first SA and frequency of attempts. For SD, higher FGRS for MD, AUD, and SD predicted later age at SD. Mediation of FGRS effects on SA and SD was more pronounced for SD than SA, strongest for AUD, DUD, and SZ FGRS and weakest for MD. Conclusions FGRS for both SA and SD and for our five psychiatric disorders impact on risk for SA and SD in a complex manner. While some of the impact of genetic risk factors for psychiatric disorders on risk for SA and SD is mediated through developing the disorders, these risks also predispose directly to suicidal behaviors.</p>}}, author = {{Kendler, Kenneth S. and Ohlsson, Henrik and Mościcki, Eve K. and Sundquist, Jan and Edwards, Alexis C. and Sundquist, Kristina}}, issn = {{0033-2917}}, keywords = {{Genetics; Psychiatric and Substance Use Disorders; Suicide attempt; Suicide Death}}, language = {{eng}}, number = {{4}}, pages = {{1639--1648}}, publisher = {{Cambridge University Press}}, series = {{Psychological Medicine}}, title = {{Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death : A Swedish national study}}, url = {{http://dx.doi.org/10.1017/S0033291721003354}}, doi = {{10.1017/S0033291721003354}}, volume = {{53}}, year = {{2023}}, }