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Processing speed is affected by early impairment in kidney function in the general elder population

Månsson, Tomas LU and Elmståhl, Sölve LU (2021) In BMC Nephrology 22(1).
Abstract

Background: Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogenesis. Processing speed is commonly impaired in cerebrovascular disease. Methods: The data was obtained from the population based study “Good aging in Skåne” (GÅS), and included 905 individuals (mean age = 68 years). We investigated the impact of impaired kidney function at baseline on the development of dementia, MCI, and impairment in specific cognitive domains at follow up 6 years later, using logistic regression models. Impaired kidney function was defined as GFR < 60 ml/min/1,73 m2. GFR was estimated... (More)

Background: Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogenesis. Processing speed is commonly impaired in cerebrovascular disease. Methods: The data was obtained from the population based study “Good aging in Skåne” (GÅS), and included 905 individuals (mean age = 68 years). We investigated the impact of impaired kidney function at baseline on the development of dementia, MCI, and impairment in specific cognitive domains at follow up 6 years later, using logistic regression models. Impaired kidney function was defined as GFR < 60 ml/min/1,73 m2. GFR was estimated from creatinine and cystatin C, using the CKD-EPI formula. Function in the cognitive domains learning and memory, language, complex attention, executive function, perceptual-motor, as well as meta-memory, and global cognitive function, was assessed using a neuropsychological test battery consisting of 12 tests. We compared the test results from follow up, with the results obtained at baseline, using linear regression models in order to assess changes in performance in cognitive domains. Results: At follow up, 14 and 158 participants had developed dementia and MCI, respectively. We did not find evidence that moderately impaired eGFR at baseline increased the odds of dementia or MCI. A decline in processing speed was associated with impaired kidney function. Conclusions: The effect on processing speed could represent early vascular implications on cognition. Even at moderately impaired kidney function, overview of cardiovascular risk factors could potentially prevent further cognitive impairment.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cognition, Decline, Dementia, Domains, Function, GFR, Impairment, Kidney, MCI, Renal
in
BMC Nephrology
volume
22
issue
1
article number
314
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85115220829
  • pmid:34548062
ISSN
1471-2369
DOI
10.1186/s12882-021-02517-5
language
English
LU publication?
yes
id
94551bfc-b0a9-4b4d-8e03-fa4677a7370d
date added to LUP
2021-10-01 11:59:22
date last changed
2024-12-01 11:25:17
@article{94551bfc-b0a9-4b4d-8e03-fa4677a7370d,
  abstract     = {{<p>Background: Chronic kidney disease, cardiovascular disease, and cognitive dysfunction are common in the elder population. There is evidence of a connection between these conditions, possibly by a shared vascular pathogenesis. Processing speed is commonly impaired in cerebrovascular disease. Methods: The data was obtained from the population based study “Good aging in Skåne” (GÅS), and included 905 individuals (mean age = 68 years). We investigated the impact of impaired kidney function at baseline on the development of dementia, MCI, and impairment in specific cognitive domains at follow up 6 years later, using logistic regression models. Impaired kidney function was defined as GFR &lt; 60 ml/min/1,73 m<sup>2</sup>. GFR was estimated from creatinine and cystatin C, using the CKD-EPI formula. Function in the cognitive domains learning and memory, language, complex attention, executive function, perceptual-motor, as well as meta-memory, and global cognitive function, was assessed using a neuropsychological test battery consisting of 12 tests. We compared the test results from follow up, with the results obtained at baseline, using linear regression models in order to assess changes in performance in cognitive domains. Results: At follow up, 14 and 158 participants had developed dementia and MCI, respectively. We did not find evidence that moderately impaired eGFR at baseline increased the odds of dementia or MCI. A decline in processing speed was associated with impaired kidney function. Conclusions: The effect on processing speed could represent early vascular implications on cognition. Even at moderately impaired kidney function, overview of cardiovascular risk factors could potentially prevent further cognitive impairment.</p>}},
  author       = {{Månsson, Tomas and Elmståhl, Sölve}},
  issn         = {{1471-2369}},
  keywords     = {{Cognition; Decline; Dementia; Domains; Function; GFR; Impairment; Kidney; MCI; Renal}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Nephrology}},
  title        = {{Processing speed is affected by early impairment in kidney function in the general elder population}},
  url          = {{http://dx.doi.org/10.1186/s12882-021-02517-5}},
  doi          = {{10.1186/s12882-021-02517-5}},
  volume       = {{22}},
  year         = {{2021}},
}