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Family history of diabetes mellitus and risk of colorectal cancer : A nationwide cohort study

Chen, Zehui LU ; Kharazmi, Elham LU ; Liang, Qunfeng LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Fallah, Mahdi LU orcid (2025) In Diabetes Research and Clinical Practice 224.
Abstract

Aims: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. Methods: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incidence ratio (SIR). Results: 11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39–1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not... (More)

Aims: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. Methods: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incidence ratio (SIR). Results: 11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39–1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset CRC. Conclusion: Leveraging one of the world's largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort study, Colorectal cancer, Family history of diabetes, Nationwide data
in
Diabetes Research and Clinical Practice
volume
224
article number
112187
publisher
Elsevier
external identifiers
  • pmid:40252778
  • scopus:105002903881
ISSN
0168-8227
DOI
10.1016/j.diabres.2025.112187
language
English
LU publication?
yes
id
94591220-b85d-4316-abed-99753ee19b0c
date added to LUP
2025-08-06 11:33:12
date last changed
2025-08-06 11:33:51
@article{94591220-b85d-4316-abed-99753ee19b0c,
  abstract     = {{<p>Aims: Studies have shown the association between personal history of diabetes mellitus (DM type 1/2) and risk of colorectal cancer (CRC). This study aims to find the association between the family history of diabetes and CRC risk. Methods: This large nationwide cohort study leveraged data from several Swedish nationwide registers (follow-up: 1964–2018) to compare the risk using standardized incidence ratio (SIR). Results: 11,784,567 individuals (668,348 with DM) were included and followed for up to 54 years (median = 28 years). Those with a personal history of DM had a 1.4-fold increased risk of CRC compared to those without DM (95 % CI: 1.39–1.45). However, the addition of a family history of DM in 1 FDR or ≥ 2 FDRs did not significantly alter the increased risk of early-onset or late-onset CRC. Conclusion: Leveraging one of the world's largest family-disease datasets, our cohort study confirmed that personal history of diabetes is associated with an increased risk of colorectal cancer, but we did not find an association between a family history of diabetes and risk of colorectal cancer.</p>}},
  author       = {{Chen, Zehui and Kharazmi, Elham and Liang, Qunfeng and Sundquist, Kristina and Sundquist, Jan and Fallah, Mahdi}},
  issn         = {{0168-8227}},
  keywords     = {{Cohort study; Colorectal cancer; Family history of diabetes; Nationwide data}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Diabetes Research and Clinical Practice}},
  title        = {{Family history of diabetes mellitus and risk of colorectal cancer : A nationwide cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2025.112187}},
  doi          = {{10.1016/j.diabres.2025.112187}},
  volume       = {{224}},
  year         = {{2025}},
}