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Thallium-technetium subtraction scintigraphy of enlarged parathyroid glands after calcitonin stimulation of parathyroid hormone secretion

Bergenfelz, A LU ; Tennvall, J LU and Ahrén, B LU (1992) In Acta radiologica (Stockholm, Sweden : 1987) 33(4). p.22-319
Abstract

To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more... (More)

To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more distinctly imaged in the scintigram after calcitonin injection, whereas in only one patient was the conventional scintigram better. Thus, the calcitonin injection improved the scintigram in 7 cases and was inferior in only one case (p = 0.031). We conclude that stimulation of parathyroid hormone secretion with calcitonin results in a better preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism.

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published
subject
keywords
Adenoma, Aged, Calcitonin, Female, Humans, Hyperparathyroidism, Male, Middle Aged, Parathyroid Hormone, Parathyroid Neoplasms, Radionuclide Imaging, Sodium Pertechnetate Tc 99m, Subtraction Technique, Thallium Radioisotopes, Journal Article, Research Support, Non-U.S. Gov't
in
Acta radiologica (Stockholm, Sweden : 1987)
volume
33
issue
4
pages
4 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:0026661628
ISSN
0284-1851
language
English
LU publication?
no
id
946b085d-6787-4a54-a9d6-8b1c45fcc5e6
date added to LUP
2017-05-10 17:50:33
date last changed
2017-08-13 05:07:34
@article{946b085d-6787-4a54-a9d6-8b1c45fcc5e6,
  abstract     = {<p>To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more distinctly imaged in the scintigram after calcitonin injection, whereas in only one patient was the conventional scintigram better. Thus, the calcitonin injection improved the scintigram in 7 cases and was inferior in only one case (p = 0.031). We conclude that stimulation of parathyroid hormone secretion with calcitonin results in a better preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism.</p>},
  author       = {Bergenfelz, A and Tennvall, J and Ahrén, B},
  issn         = {0284-1851},
  keyword      = {Adenoma,Aged,Calcitonin,Female,Humans,Hyperparathyroidism,Male,Middle Aged,Parathyroid Hormone,Parathyroid Neoplasms,Radionuclide Imaging,Sodium Pertechnetate Tc 99m,Subtraction Technique,Thallium Radioisotopes,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {4},
  pages        = {22--319},
  publisher    = {John Wiley & Sons},
  series       = {Acta radiologica (Stockholm, Sweden : 1987)},
  title        = {Thallium-technetium subtraction scintigraphy of enlarged parathyroid glands after calcitonin stimulation of parathyroid hormone secretion},
  volume       = {33},
  year         = {1992},
}