Thallium-technetium subtraction scintigraphy of enlarged parathyroid glands after calcitonin stimulation of parathyroid hormone secretion
(1992) In Acta radiologica (Stockholm, Sweden : 1987) 33(4). p.22-319- Abstract
To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more... (More)
To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more distinctly imaged in the scintigram after calcitonin injection, whereas in only one patient was the conventional scintigram better. Thus, the calcitonin injection improved the scintigram in 7 cases and was inferior in only one case (p = 0.031). We conclude that stimulation of parathyroid hormone secretion with calcitonin results in a better preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism.
(Less)
- author
- Bergenfelz, A LU ; Tennvall, J LU and Ahrén, B LU
- publishing date
- 1992-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adenoma, Aged, Calcitonin, Female, Humans, Hyperparathyroidism, Male, Middle Aged, Parathyroid Hormone, Parathyroid Neoplasms, Radionuclide Imaging, Sodium Pertechnetate Tc 99m, Subtraction Technique, Thallium Radioisotopes, Journal Article, Research Support, Non-U.S. Gov't
- in
- Acta radiologica (Stockholm, Sweden : 1987)
- volume
- 33
- issue
- 4
- pages
- 4 pages
- publisher
- SAGE Publications
- external identifiers
-
- scopus:0026661628
- pmid:1321652
- ISSN
- 0284-1851
- language
- English
- LU publication?
- no
- id
- 946b085d-6787-4a54-a9d6-8b1c45fcc5e6
- date added to LUP
- 2017-05-10 17:50:33
- date last changed
- 2024-01-13 20:46:48
@article{946b085d-6787-4a54-a9d6-8b1c45fcc5e6,
abstract = {{<p>To improve the sensitivity of thallium-technetium subtraction scintigraphy for preoperative localization procedure of enlarged parathyroid glands in primary hyperparathyroidism, we administered calcitonin intramuscularly 4 hours before the scintigraphy in 14 consecutive patients. Injection of calcitonin reduced plasma levels of ionized calcium from 1.47 +/- 0.10 mmol/l to 1.41 +/- 0.09 mmol/l (p less than 0.01). Concomitantly, serum levels of intact parathyroid hormone increased from 6.4 +/- 2.5 pmol/l to 7.9 +/- 2.6 pmol/l (p less than 0.001). The scintigram after calcitonin injection visualized 11 adenomas (sensitivity 78%) compared to only 9 (sensitivity 64%) in conventional scintigrams. In addition, 5 of the adenomas were more distinctly imaged in the scintigram after calcitonin injection, whereas in only one patient was the conventional scintigram better. Thus, the calcitonin injection improved the scintigram in 7 cases and was inferior in only one case (p = 0.031). We conclude that stimulation of parathyroid hormone secretion with calcitonin results in a better preoperative localization of enlarged parathyroid glands in primary hyperparathyroidism.</p>}},
author = {{Bergenfelz, A and Tennvall, J and Ahrén, B}},
issn = {{0284-1851}},
keywords = {{Adenoma; Aged; Calcitonin; Female; Humans; Hyperparathyroidism; Male; Middle Aged; Parathyroid Hormone; Parathyroid Neoplasms; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Subtraction Technique; Thallium Radioisotopes; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{4}},
pages = {{22--319}},
publisher = {{SAGE Publications}},
series = {{Acta radiologica (Stockholm, Sweden : 1987)}},
title = {{Thallium-technetium subtraction scintigraphy of enlarged parathyroid glands after calcitonin stimulation of parathyroid hormone secretion}},
volume = {{33}},
year = {{1992}},
}