Advanced

Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup

Wahlund, Lars-Olof; Almkvist, Ove; Blennow, Kaj; Engedahl, Knut; Johanson, Aki LU ; Waldemar, Gunhild and Wolf, Henrike (2005) In Topics in Magnetic Resonance Imaging 16(6). p.427-437
Abstract
BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease.

METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way.

... (More)
BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease.

METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way.

CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dementia workup, medial temporal lobe, Alzheimer disease, specificity, sensitivity, likelihood ratios, evidence-based medicine, magnetic resonance imaging, diagnosis
in
Topics in Magnetic Resonance Imaging
volume
16
issue
6
pages
427 - 437
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:33750689880
ISSN
0899-3459
DOI
10.1097/01.rmr.0000245463.36148.12
language
English
LU publication?
yes
id
b4ec9a37-1997-4f64-9b09-6864949514d7 (old id 949832)
date added to LUP
2008-01-30 12:23:15
date last changed
2017-01-01 06:41:49
@article{b4ec9a37-1997-4f64-9b09-6864949514d7,
  abstract     = {BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. <br/><br>
METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. <br/><br>
CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.},
  author       = {Wahlund, Lars-Olof and Almkvist, Ove and Blennow, Kaj and Engedahl, Knut and Johanson, Aki and Waldemar, Gunhild and Wolf, Henrike},
  issn         = {0899-3459},
  keyword      = {Dementia workup,medial temporal lobe,Alzheimer disease,specificity,sensitivity,likelihood ratios,evidence-based medicine,magnetic resonance imaging,diagnosis},
  language     = {eng},
  number       = {6},
  pages        = {427--437},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Topics in Magnetic Resonance Imaging},
  title        = {Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup},
  url          = {http://dx.doi.org/10.1097/01.rmr.0000245463.36148.12},
  volume       = {16},
  year         = {2005},
}