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Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease : a systematic review

Solberg, Felix and Ohlsson, Bodil LU (2020) In Scandinavian Journal of Gastroenterology
Abstract

Objectives: Crohn’s disease and ulcerative colitis are associated with an increased risk to develop anemia, cutaneous diseases, liver diseases, malignancy, osteoporosis, rheumatic diseases, thromboembolism and uveitis. The association between these diseases and microscopic colitis (MC) is not known. The aim of the present systematic review was to examine associations between MC and diseases observed in association with Crohn’s disease and ulcerative colitis. Material and methods: According to the review protocol, original articles which described the prevalence of abovementioned diseases in relation to MC, were searched for in PubMed, Embase and Web of Science. Results: After exclusion of duplicates, 928 articles remained. Based on... (More)

Objectives: Crohn’s disease and ulcerative colitis are associated with an increased risk to develop anemia, cutaneous diseases, liver diseases, malignancy, osteoporosis, rheumatic diseases, thromboembolism and uveitis. The association between these diseases and microscopic colitis (MC) is not known. The aim of the present systematic review was to examine associations between MC and diseases observed in association with Crohn’s disease and ulcerative colitis. Material and methods: According to the review protocol, original articles which described the prevalence of abovementioned diseases in relation to MC, were searched for in PubMed, Embase and Web of Science. Results: After exclusion of duplicates, 928 articles remained. Based on relevancy of their title, abstract or type of article, 16 articles were ordered in full text and after assessment, nine articles could be included in the review. A second research strategy with individual diseases rendered further two articles. Seven articles covered malignancy/neoplasia, where four showed no association with malignancy and three a reduced association compared with controls. Four articles covering rheumatic diseases showed an association between these diseases and MC. One study showed an association between MC and osteoporosis, whereas one did not. One study showed an association between MC and cutaneous diseases, whereas anemia, eye diseases and thromboembolism showed no associations. Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC.

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Contribution to journal
publication status
epub
subject
keywords
Collagenous colitis, lymphocytic colitis, microscopic colitis, systematic review
in
Scandinavian Journal of Gastroenterology
publisher
Taylor & Francis
external identifiers
  • scopus:85082316917
  • pmid:32182146
ISSN
0036-5521
DOI
10.1080/00365521.2020.1739325
language
English
LU publication?
yes
id
94e54b60-aa01-4a23-8b7b-b81cbad362df
date added to LUP
2020-04-07 12:49:24
date last changed
2020-10-27 01:12:18
@article{94e54b60-aa01-4a23-8b7b-b81cbad362df,
  abstract     = {<p>Objectives: Crohn’s disease and ulcerative colitis are associated with an increased risk to develop anemia, cutaneous diseases, liver diseases, malignancy, osteoporosis, rheumatic diseases, thromboembolism and uveitis. The association between these diseases and microscopic colitis (MC) is not known. The aim of the present systematic review was to examine associations between MC and diseases observed in association with Crohn’s disease and ulcerative colitis. Material and methods: According to the review protocol, original articles which described the prevalence of abovementioned diseases in relation to MC, were searched for in PubMed, Embase and Web of Science. Results: After exclusion of duplicates, 928 articles remained. Based on relevancy of their title, abstract or type of article, 16 articles were ordered in full text and after assessment, nine articles could be included in the review. A second research strategy with individual diseases rendered further two articles. Seven articles covered malignancy/neoplasia, where four showed no association with malignancy and three a reduced association compared with controls. Four articles covering rheumatic diseases showed an association between these diseases and MC. One study showed an association between MC and osteoporosis, whereas one did not. One study showed an association between MC and cutaneous diseases, whereas anemia, eye diseases and thromboembolism showed no associations. Conclusions: Due to short follow-up time in small studies, with selection bias due to exclusion of former or prevalent malignancy in an older population, no conclusions can be drawn concerning the true association between MC and malignancy. Rheumatic diseases seem to be associated with MC.</p>},
  author       = {Solberg, Felix and Ohlsson, Bodil},
  issn         = {0036-5521},
  language     = {eng},
  month        = {03},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease : a systematic review},
  url          = {http://dx.doi.org/10.1080/00365521.2020.1739325},
  doi          = {10.1080/00365521.2020.1739325},
  year         = {2020},
}