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Robustness of metabolic maps

Ahrén, Dag LU and Ouzounis, Christos (2004) In Journal of Bioinformatics and Computational Biology 2(3). p.589-593
Abstract
With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In order to be able to use incomplete data for metabolic reconstruction, the inherent properties of this procedure need to be investigated. In this short note, we describe the robustness and predictive power of metabolic reconstructions using partial information from Schizosaccharomyces pombe. We also discuss the implications of the results on... (More)
With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In order to be able to use incomplete data for metabolic reconstruction, the inherent properties of this procedure need to be investigated. In this short note, we describe the robustness and predictive power of metabolic reconstructions using partial information from Schizosaccharomyces pombe. We also discuss the implications of the results on reference genome projects as well as other large-scale sequencing data. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Metabolic reconstruction metabolic maps genome analysis robustness analysis biochemical pathways
in
Journal of Bioinformatics and Computational Biology
volume
2
issue
3
pages
589 - 593
publisher
Imperial College Press
external identifiers
  • scopus:4644254273
ISSN
0219-7200
DOI
10.1142/S021972000400079X
language
English
LU publication?
no
id
b6fe1295-133e-4c28-a53d-7154df37c088 (old id 952546)
date added to LUP
2008-01-29 13:24:19
date last changed
2017-01-01 05:18:06
@article{b6fe1295-133e-4c28-a53d-7154df37c088,
  abstract     = {With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In order to be able to use incomplete data for metabolic reconstruction, the inherent properties of this procedure need to be investigated. In this short note, we describe the robustness and predictive power of metabolic reconstructions using partial information from Schizosaccharomyces pombe. We also discuss the implications of the results on reference genome projects as well as other large-scale sequencing data.},
  author       = {Ahrén, Dag and Ouzounis, Christos},
  issn         = {0219-7200},
  keyword      = {Metabolic reconstruction
metabolic maps
genome analysis
robustness analysis
biochemical pathways},
  language     = {eng},
  number       = {3},
  pages        = {589--593},
  publisher    = {Imperial College Press},
  series       = {Journal of Bioinformatics and Computational Biology},
  title        = {Robustness of metabolic maps},
  url          = {http://dx.doi.org/10.1142/S021972000400079X},
  volume       = {2},
  year         = {2004},
}